Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets

The Biochemical Journal
Juan A Rosado, S O Sage

Abstract

Physical coupling between inositol 1,4,5-trisphosphate (IP(3)) receptors and transient receptor potential (Trp) channels has been demonstrated in both transfected and normal cells as a candidate mechanism for the activation of store-mediated Ca(2+) entry (SMCE). We have investigated the properties of the coupling between the type II IP(3) receptor and naturally expressed human Trp1 (hTrp1) in human platelets. Treatment with xestospongin C, an inhibitor of IP(3) receptor function, abolished SMCE and coupling between the IP(3) receptor and hTrp1. The coupling was activated by depletion of the intracellular Ca(2+) stores, and was reversed by refilling of the stores. We have also examined the role of actin filaments in the activation and maintenance of the coupling. Stabilization of the cortical actin network with jasplakinolide prevented the coupling, indicating that, as with secretion, the actin filaments at the cell periphery act as a negative clamp which prevents constitutive coupling. In addition, the actin cytoskeleton plays a positive role, since disruption of the actin network inhibited the coupling when the Ca(2+) stores were depleted. These results provide strong evidence for the activation of SMCE by a secretion-like cou...Continue Reading

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Citations

Nov 9, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·David Stegner, Bernhard Nieswandt
Nov 24, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·Jih-Pyang WangChun-Nan Lin
Nov 12, 2005·Pflügers Archiv : European journal of physiology·Shiwei CaiKenneth T Izutsu
Jun 12, 2008·Pflügers Archiv : European journal of physiology·David Varga-SzaboBernhard Nieswandt
Mar 10, 2004·Biochemical Pharmacology·Pedro C RedondoJuan A Rosado
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Aug 6, 2002·Trends in Cardiovascular Medicine·Juan A Rosado, Stewart O Sage
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