PMID: 6506090Nov 1, 1984

Activation of styrene to styrene oxide in hepatocytes and subcellular fractions of rat liver

Toxicology Letters
G BelvedereH Vainio

Abstract

The oxidation of styrene to styrene oxide and the hydration of this metabolite to styrene glycol was investigated in hepatocytes, 9000 x g supernatant (S9) and the microsomal fraction from rat liver. Similar amounts of free styrene oxide were found in microsomes, hepatocytes and S9. However, on the basis of the formation of styrene glycol and the depletion of glutathione (GSH), it appeared that hepatocytes were the most active system in the metabolism of styrene, followed by S9 and microsomes.

References

Oct 1, 1976·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M SalmonaS Garattini
Jun 1, 1977·Bulletin of Environmental Contamination and Toxicology·D R Stoltz, R J Whitey
Jul 1, 1979·Mutation Research·L Busk
Sep 1, 1976·Scandinavian Journal of Work, Environment & Health·H VainioO Pelkonen
Jan 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·L V BECKB DUNCAN

Related Concepts

Styrene oxide, (S)-isomer
Styrene glycol, (S)-isomer
Metazoa
Cell Survival
Epoxy Compounds
Ethers, Cyclic
Ethylene Glycols
Reduced Glutathione
Liver
NADP

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