PMID: 6407405Jun 1, 1983Paper

Activation of the alternative pathway of complement by monosodium urate monohydrate crystals and other inflammatory particles

Annals of the Rheumatic Diseases
M DohertyP A Dieppe

Abstract

Activation of serum C3 by monosodium urate monohydrate (MSU) crystals and other particles was determined by immunofixation following electrophoretic separation of C3 and its activation products. Densitometry allowed quantitation of results. MSU, hydroxyapatite, brushite, and calcium pyrophosphate dihydrate crystals split C3 under conditions which demonstrate activation via the alternative pathway (AP). Quantitatively similar results were obtained in immunoglobulin deficient serum. Activation was crystal specific and was reduced by heating, grinding, sonication, and aging of crystals. Other inflammatory particles (e.g., blackthorn) activated C3 via the AP: noninflammatory particles (e.g., diamond) caused insignificant activation. It is suggested that particle-induced activation of the alternative pathway of complement may be important in the initiation of crystal-induced synovitis.

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Citations

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·R LagierJ C Gerster
May 27, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Gilbert NgYan Shi
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Jul 22, 2008·Current Rheumatology Reports·George Nuki
Nov 18, 2015·Immunology·Martha TriantafilouKathy Triantafilou
Sep 18, 2014·European Journal of Immunology·Ling-Ling AnMichael Fung
Mar 3, 2010·Immunological Reviews·Yan ShiGilbert Ng
Jun 16, 2005·Rheumatology·N Dalbeth, D O Haskard
Sep 1, 1984·Journal of the Royal Society of Medicine·T D KennedyJ T Scott

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