PMID: 7539218May 1, 1995Paper

Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma

The American Journal of Physiology
Vickie E BaracosA L Goldberg

Abstract

Rats implanted with Yoshida ascites hepatoma (YAH) show a rapid and selective loss of muscle protein due mainly to a marked increase (63-95%) in the rate of protein degradation (compared with rates in muscles of pair-fed controls). To define which proteolytic pathways contribute to this increase, epitrochlearis muscles from YAH-bearing and control rats were incubated under conditions that modify different proteolytic systems. Overall proteolysis in either group of rats was not affected by removal of Ca2+ or by blocking the Ca(2+)-dependent proteolytic system. Inhibition of lysosomal function with methylamine reduced proteolysis (-12%) in muscles from YAH-bearing rats, but not in muscles of pair-fed rats. When ATP production was also inhibited, the remaining accelerated proteolysis in muscles of tumor-bearing rats fell to control levels. Muscles of YAH-bearing rats showed increased levels of ubiquitin-conjugated proteins and a 27-kDa proteasome subunit in Western blot analysis. Levels of mRNA encoding components of proteolytic systems were quantitated using Northern hybridization analysis. Although their total RNA content decreased 20-38%, pale muscles of YAH-bearing rats showed increased levels of ubiquitin mRNA (590-880%) and ...Continue Reading

References

Jan 1, 1992·Annual Review of Biochemistry·A Hershko, A Ciechanover
Nov 1, 1991·The British Journal of Nutrition·V E BaracosM Marie
Apr 15, 1987·The Biochemical Journal·J M FaganA L Goldberg
Nov 1, 1987·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J F Dice
Dec 1, 1988·Diabetes/metabolism Reviews·I C KettelhutA L Goldberg
Dec 1, 1986·Metabolism: Clinical and Experimental·B B LowellM N Goodman
Dec 1, 1993·The Journal of Clinical Investigation·P CostelliF M Baccino
Jan 1, 1993·British Journal of Cancer·L TessitoreF M Baccino

❮ Previous
Next ❯

Citations

Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Olasunkanmi A J AdegokeSimon S Wing
Oct 10, 2002·American Journal of Physiology. Cell Physiology·Gary M DiffeeDonna O McCarthy
Apr 22, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jennifer M SacheckAlfred L Goldberg
Aug 19, 2008·Biological Research for Nursing·Sadeeka Al-Majid, Haidee Waters
Sep 20, 2008·Journal of Applied Physiology·Brian T SteffenFrank W Booth
May 23, 2018·Oxidative Medicine and Cellular Longevity·Fabio PennaPaola Costelli
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Marie-Chantal FargesVickie E Baracos
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M BossolaG B Doglietto
Feb 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Saul R Powell
Mar 22, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana Belén Gómez-SanMiguelAsunción López-Calderón
Dec 12, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Helene Nissrine Daou
Jun 14, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Paola Costelli, Francesco M Baccino
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aminah JatoiUNKNOWN North Central Cancer Treatment Group
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Aminah Jatoi
Jun 9, 2005·American Journal of Physiology. Endocrinology and Metabolism·Michelle L MackenzieVickie E Baracos
Oct 18, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrzej Wiȩcek
May 2, 2003·American Journal of Physiology. Endocrinology and Metabolism·Xiaoyan SunJames Lu
Jun 15, 2011·The Journal of Physiology·Despina ConstantinPaul L Greenhaff
Apr 6, 2012·Journal of Cachexia, Sarcopenia and Muscle·Kunihiro Sakuma, Akihiko Yamaguchi
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Brian J KrawiecCharles H Lang
Jun 28, 2011·Critical Reviews in Clinical Laboratory Sciences·Simon S WingR Thomas Jagoe
Feb 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Estíbaliz CastilleroAsunción López-Calderón
Apr 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aldrin V GomesSue C Bodine
Mar 13, 2019·American Journal of Physiology. Endocrinology and Metabolism·Juulia H LautaojaJuha J Hulmi
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Tricia A BabcockN Joseph Espat
Nov 13, 2008·The Journal of Physiology·Joanne E MallinsonPaul L Greenhaff
Jul 18, 2009·Journal of Applied Physiology·S M PhillipsM J Rennie
Nov 25, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lydie CombaretSimon S Wing
Sep 24, 2009·American Journal of Physiology. Endocrinology and Metabolism·Priyanka SundaramSimon S Wing
Jul 22, 2019·Biochimie·Daniel Taillandier, Cécile Polge
Feb 3, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hyo-Gun KimGustavo A Nader
Jan 21, 2021·Biomolecules·Dina Aweida, Shenhav Cohen
Mar 31, 2021·Journal of Cachexia, Sarcopenia and Muscle·Agnès Martin, Damien Freyssenet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.