Activation of the carotid body increases directly recorded cardiac sympathetic nerve activity and coronary blood flow in conscious sheep.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Mridula PachenRohit Ramchandra

Abstract

Activation of the carotid body (CB) using intracarotid potassium cyanide (KCN) injection increases coronary blood flow (CoBF). This increase in CoBF is considered to be mediated by co-activation of both the sympathetic and parasympathetic nerves to the heart. However, whether cardiac sympathetic nerve activity (cardiac SNA) actually increases during CB activation has not been determined previously. We hypothesized that activation of the CB would increase directly recorded cardiac SNA, which would cause coronary vasodilatation. Experiments were conducted in conscious sheep implanted with electrodes to record cardiac SNA and diaphragmatic electromyography (dEMG), flow probes to record CoBF and cardiac output, and a catheter to record arterial pressure. Intracarotid KCN injection was used to activate the CB. To eliminate the contribution of metabolic demand on coronary flow, the heart was paced at a constant rate during CB chemoreflex stimulation. Intracarotid KCN injection resulted in a significant increase in directly recorded cardiac SNA frequency (from 24 ± 2 to 40 ± 4 bursts/min; P < 0.05) as well as a dose-dependent increase in mean arterial pressure (79 ± 15 to 88 ± 14 mmHg; P < 0.01) and CoBF (75 ± 37 vs. 86 ± 42 mL/min; P...Continue Reading

References

Jan 1, 1975·Acta Anatomica·J A Armour, W C Randall
Dec 1, 1985·The American Journal of Physiology·B R Ito, E O Feigl
Nov 1, 1971·The American Journal of Physiology·I NinomiyaH Irisawa
Nov 1, 1969·Circulation Research·E O Feigl
Jan 1, 1968·British Journal of Anaesthesia·T J Biscoe, R A Millar
Feb 1, 1967·Circulation Research·E O Feigl
Jan 1, 1983·Physiological Reviews·E O Feigl
Mar 1, 1981·Circulation Research·M ZimpferS F Vatner
Oct 1, 1993·The American Journal of Physiology·K MatsukawaN Nishiura
Aug 1, 1993·Circulation Research·J K Miyashiro, E O Feigl
Jul 1, 1996·The American Journal of Physiology·G F DiBonaS Y Jones
Oct 10, 1997·Hypertension·K G FranchiniE M Krieger
Apr 8, 1998·Journal of the Autonomic Nervous System·L Feliciano, R J Henning
Aug 30, 2000·Respiration Physiology·P G Guyenet
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S F Morrison
Jan 1, 1990·The European Journal of Neuroscience·C. EyzaguirreJ. W. Woodbury
Dec 1, 1955·The American Journal of Physiology·A ALELLAL N KATZ
Jan 1, 1962·The American Journal of Physiology·H FEINBERGE BOYD
Mar 1, 1955·The American Journal of Anatomy·N J MIZERES
Jan 31, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anna M D WatsonClive N May
Sep 1, 1950·The American Journal of Physiology·E L FOLTZA J WEISS
Jan 20, 2007·Respiratory Physiology & Neurobiology·Rodrigo IturriagaJulio Alcayaga
Apr 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·A M D WatsonC N May
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
Aug 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Valdir A BragaRobin L Davisson
Jan 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rohit RamchandraClive N May
Oct 2, 2012·Seminars in Cell & Developmental Biology·Colin A Nurse, Nikol A Piskuric
Sep 5, 2013·Nature Communications·Fiona D McBrydeJulian F R Paton
Jun 3, 2014·Experimental Physiology·Jessica KåhlinLars I Eriksson

❮ Previous
Next ❯

Citations

Apr 30, 2021·Nature and Science of Sleep·Hong Peng LiQing Yun Li
Jun 15, 2021·Frontiers in Physiology·Mridula PachenRohit Ramchandra

❮ Previous
Next ❯

Software Mentioned

Spike
Spike2

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.