PMID: 3752282Sep 1, 1986Paper

Activation of the central vasopressin system: a common pathway for several centrally acting pressor agents

The American Journal of Physiology
K A Gruber, S L Eskridge

Abstract

Hypertonic saline (HS) and angiotensin II (ANG II) administered centrally or peripherally produce a forebrain-mediated central nervous system-(CNS) dependent pressor action. Although the majority of these effects are due to increased central sympathetic drive and inhibition of the cardiac baroreceptor reflex, evidence from peripheral infusions of vasopressin (Vp) receptor antagonists have suggested that part of the blood pressure increase may be due to circulating Vp. We now report that blockade of CNS Vp receptors in rats, via a fourth ventricle infusion of a Vp receptor antagonist, attenuated greater than 70% of the pressor response to lateral ventricle infusion of HS, ANG II, or hypertonic glucose (HG). Intravenous administration of the Vp antagonist could block only 40% of the HS response. When lateral ventricle infusion of HS was performed in rats with a hereditary lack of Vp (diabetes insipidic rats) no pressor response was obtained. Because centrally administered Vp has autonomic nervous system effects that are similar to those induced by HS or ANG II, our results suggest that CNS Vp may provide a link between forebrain acting pressor agents and autonomic nervous system regulation. Finally, HG produced a pressor effect t...Continue Reading

Citations

Dec 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Britta Veitenheimer, John W Osborn
Nov 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Britta Veitenheimer, John W Osborn

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