Activation of the CXCL16/CXCR6 Axis by TNF-α Contributes to Ectopic Endometrial Stromal Cells Migration and Invasion

Reproductive Sciences
Yaoming PengJun Lin

Abstract

The activation of systemic and local inflammatory mechanisms, including elevated levels of chemokines and proinflammatory cytokines in endometriosis progression, is becoming more evident in the recent years. Here, we report the involvement of CXC chemokine 16 (CXCL16) and its sole receptor, CXC chemokine receptor 6 (CXCR6), in pathophysiology of endometriosis. Expression of CXCL16, but not CXCR6, was significantly upregulated in endometriotic lesions when compared to control endometrium. Additionally, serum CXCL16 was significantly elevated in women with endometriosis when compared to control group. Moreover, blockade of the CXCL16/CXCR6 axis by CXCR6 small-interfering RNA reduced the migration and invasion of ectopic endometrial stromal cells (EESCs) followed by decreased phosphorylation of ERK1/2. Furthermore, TNF-α treatment induced the expression of CXCL16 in EESCs. In conclusion, these results suggest that CXCL16/CXCR6 axis, whose expression was enhanced by TNF-α, may be associated with the increased motility of EESCs, through regulation of ERK1/2 signaling, thus contributing to the development of endometriosis. These findings indicate that the CXCL16/CXCR6 axis may contribute to the progression of endometriosis and could ...Continue Reading

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Citations

Jan 24, 2020·American Journal of Reproductive Immunology : AJRI·Jia-Wei ShiMing-Qing Li
Mar 9, 2020·Journal of Neuroinflammation·Yajing WeiShuzhong Yao
Apr 4, 2021·International Journal of Molecular Sciences·Jan KorbeckiIrena Baranowska-Bosiacka
Mar 1, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Neha R DhokeAmitava Das
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Sabina SanegreRosa Noguera
Jul 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Nan LiuHui-Fang Zhou

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