Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Jing JinZhiying Huang

Abstract

Triptolide, an active ingredient extracted from the Chinese herb Tripterygium wilfordii Hook f., has multiple pharmacological properties, including anti-inflammatory, immune-modulatory, and anti-proliferative activities. However, the hepatotoxicity of triptolide always limits its clinical applications. Farnesoid X receptor (FXR) is a ligand-activated transcription factor that plays a key role in hepatoprotection through the maintenance of liver metabolism homeostasis. This study explored the role of FXR in triptolide-induced cytotoxicity and investigated whether activation of FXR can protect against triptolide-induced liver injury. The role of FXR in triptolide-induced cytotoxicity was investigated in HepG2 cells. In addition, the protective effect of the selective FXR agonist GW4064 on triptolide-induced hepatotoxicity was explored in BALB/c mice. HepG2 cells were transient transfected with FXR expression plasmid or FXR-siRNA. The cytotoxicity was compared using the MTT assay. The extent of liver injury was assessed by histopathology and serum aminotransferases. The expression of FXR and its target genes were detected by Western blot and qRT-PCR. The transient overexpression of FXR protected against triptolide-induced cell dea...Continue Reading

References

Oct 4, 1972·Journal of the American Chemical Society·S M KupchanR F Bryan
Jun 9, 1999·Molecular Cell·H WangB M Forman
Feb 3, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zhinan MeiXiangliang Yang
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yanqiao ZhangPeter A Edwards
Oct 1, 2008·Cell Research·Yan-Dong WangWendong Huang
Feb 9, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stephanie J LeuenrothCraig M Crews
Jun 25, 2010·Molecular Endocrinology·Florence Ying LeePeter A Edwards
May 21, 2011·Toxicology Letters·Xiang XueJin Ren
Apr 16, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lingyun XuXiangliang Yang
Sep 26, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiao-Mei ZhuangHua Li
Mar 5, 2014·Advanced Biomedical Research·Ahmad MovahedianMahtab Keshvari
Apr 10, 2014·Journal of Traditional and Complementary Medicine·Thirumalaiswamy BalasubramanianTapan Kumar Chatterjee

❮ Previous
Next ❯

Citations

Apr 5, 2016·Chemico-biological Interactions·Dan-Qian ChenYing-Yong Zhao
Oct 19, 2016·Journal of Digestive Diseases·Zhi Qing Yuan, Ke Wei Li
Jun 9, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Pan ZhaoUNKNOWN Acute Liver Failure Study Team (ALFST)
May 26, 2017·Frontiers in Pharmacology·Jing YangZhenzhou Jiang
Aug 17, 2018·Current Drug Metabolism·Wei SongZhihong Peng
May 17, 2017·Phytotherapy Research : PTR·Zhihua LiBikui Zhang
Sep 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mengzhi ZouXinzhi Wang
Mar 12, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Wan PengFei Li
Dec 10, 2020·Medicinal Research Reviews·Yanqiong ZhangNa Lin
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shengli WangXinchun Wang
Nov 12, 2021·Human & Experimental Toxicology·Hai-Yan JiangYong Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.