Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system

PloS One
Jennifer E RichardKarolina P Skibicka

Abstract

The gut/brain peptide, glucagon like peptide 1 (GLP-1), suppresses food intake by acting on receptors located in key energy balance regulating CNS areas, the hypothalamus or the hindbrain. Moreover, GLP-1 can reduce reward derived from food and motivation to obtain food by acting on its mesolimbic receptors. Together these data suggest a neuroanatomical segregation between homeostatic and reward effects of GLP-1. Here we aim to challenge this view and hypothesize that GLP-1 can regulate food reward behavior by acting directly on the hindbrain, the nucleus of the solitary tract (NTS), GLP-1 receptors (GLP-1R). Using two models of food reward, sucrose progressive ratio operant conditioning and conditioned place preference for food in rats, we show that intra-NTS microinjections of GLP-1 or Exendin-4, a stable analogue of GLP-1, inhibit food reward behavior. When the rats were given a choice between palatable food and chow, intra-NTS Exendin-4 treatment preferentially reduced intake of palatable food but not chow. However, chow intake and body weight were reduced by the NTS GLP-1R activation if chow was offered alone. The NTS GLP-1 activation did not alter general locomotor activity and did not induce nausea, measured by PICA. We ...Continue Reading

References

Oct 1, 1990·Pharmacology, Biochemistry, and Behavior·B A GosnellM J Majchrzak
Jan 1, 1986·Journal of Neuroscience Research·V K HanP K Lund
Jan 1, 1988·Physiology & Behavior·L Hernandez, B G Hoebel
Jun 1, 1984·Physiology & Behavior·R C Ritter, G L Edwards
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 18, 2002·Neuron·Clifford B SaperJoel K Elmquist
Jun 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rafael R SchickVolker Schusdziarra
Jul 3, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Harvey J GrillJoel M Kaplan
Aug 4, 2004·Neuroscience and Biobehavioral Reviews·Albert Adell, Francesc Artigas
Mar 19, 2005·The Journal of Comparative Neurology·Huiyuan ZhengHans-Rudolf Berthoud
Aug 16, 2005·Nature·Glenda C HarrisGary Aston-Jones
Feb 24, 2007·Physiology & Behavior·Pawel K Olszewski, Allen S Levine
Feb 28, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S E la FleurR A H Adan
Apr 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amy M NaleidAllen S Levine
Dec 7, 2007·Cell Metabolism·Harvey J GrillMatthew R Hayes
Sep 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elyssa B MargolisHoward L Fields
Dec 2, 2008·Cell Metabolism·Frank ReimannFiona M Gribble
Jun 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H ZhengH-R Berthoud
Mar 17, 2010·Physiology & Behavior·Matthew R HayesScott E Kanoski
Mar 27, 2010·Physiology & Behavior·Angie M CasonGary Aston-Jones
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Zivjena Vucetic, Teresa M Reyes
Oct 22, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Linda Rinaman
May 4, 2011·Physiology & Behavior·Pawel K OlszewskiAllen S Levine
Oct 11, 2011·Current Opinion in Neurobiology·Hans-Rudolf Berthoud
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amanda M DossatDiana L Williams
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suzanne L DicksonKarolina P Skibicka

❮ Previous
Next ❯

Citations

Apr 12, 2016·Current Opinion in Behavioral Sciences·Matthew R Hayes, Heath D Schmidt
Jan 3, 2016·Psychoneuroendocrinology·Rozita H AnderbergKarolina P Skibicka
Dec 25, 2015·Pharmacology, Biochemistry, and Behavior·Kimberly A Bernosky-SmithCaroline E Bass
Jan 19, 2016·Biology of Sex Differences·Jennifer E RichardKarolina P Skibicka
Jul 28, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Samantha M FortinMitchell F Roitman
Jul 6, 2015·International Journal of Cardiology·Zhixing FanJian Yang
May 21, 2016·Frontiers in Computational Neuroscience·Shayan Tabe-Bordbar, Thomas J Anastasio
Jun 22, 2016·The Journal of Endocrinology·Yolanda Diz-ChavesFederico Mallo
Oct 27, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amber L AlhadeffMatthew R Hayes
Jan 26, 2017·Physiology & Behavior·Elizabeth G Mietlicki-BaaseMatthew R Hayes
Jul 6, 2017·Expert Opinion on Drug Safety·Marc S Rendell
Feb 8, 2018·Physiology·J W Maniscalco, L Rinaman
Jul 19, 2018·The Journal of Comparative Neurology·J Patrick CardLinda Rinaman
Apr 9, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rosa M LeonMatthew R Hayes
Sep 21, 2018·Frontiers in Psychiatry·Ted M HsuMitchell F Roitman
Aug 21, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stefan Trapp, Simon C Cork
Oct 28, 2018·Science China. Life Sciences·Song WenLigang Zhou
Feb 22, 2017·The Journal of Clinical Investigation·Ronald P GaykemaMichael M Scott
Apr 1, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Scott E KanoskiKarolina P Skibicka
Oct 4, 2018·European Eating Disorders Review : the Journal of the Eating Disorders Association·Marta G Novelle, Carlos Diéguez
Dec 12, 2018·Frontiers in Endocrinology·Jordan RowlandsRodrigo Carlessi
Sep 1, 2016·Alcoholism, Clinical and Experimental Research·Gunnar SørensenMorgane Thomsen
Mar 28, 2020·JCI Insight·Sanaz GaberyWouter Frederik Johan Hogendorf
Jan 17, 2021·Molecular Metabolism·Ruth HanssenMarc Tittgemeyer
Feb 12, 2021·Journal of Psychopharmacology·Ilijana BabicKatrina Weston-Green
Jan 11, 2021·Peptides·Carolina R Cawthon, Claire B de La Serre
Mar 21, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eva Guerrero-HreinsPriya Sumithran

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

GraphPad

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.