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Activation of the guanylate cyclase-guanosine 3'5' monophosphate system of colonic mucosa by n-methyl-n'-nitro-n-nitrosoguanidine

Cancer

Nov 1, 1977

F R Derubertis, P A Craven

PMID: 21743

Abstract

The effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the guanylate cyclase (GC)-guanosine 3'5' monophosphate (cGMP) system of rat colonic mucosa were studied. MNNG (1 mM) increased colonic mucosal cGMP from 1.8 +/- 0.2 to 22.5 +/- 2.7 pmol/mg protein in 5 minutes. Increases in ...read more

Mentioned in this Paper

Methylnitronitrosoguanidine
Taenia Coli
Structure of Intestinal Gland
Guanylate Cyclase
Cyclic GMP
Liver
Paper Details
References
  • References20
  • Citations6
12

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sGC Modulators

Soluble guanylate cyclase (sGC) stimulators and activators have been developed to treat patients with pulmonary hypertension and heart failure, respectively. Recently these sGC modulators have been explored for the treatment of fibrosis. Discover the latest research on sGC modulators here.

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Activation of the guanylate cyclase-guanosine 3'5' monophosphate system of colonic mucosa by n-methyl-n'-nitro-n-nitrosoguanidine

Cancer

Nov 1, 1977

F R Derubertis, P A Craven

PMID: 21743

DOI:

Abstract

The effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the guanylate cyclase (GC)-guanosine 3'5' monophosphate (cGMP) system of rat colonic mucosa were studied. MNNG (1 mM) increased colonic mucosal cGMP from 1.8 +/- 0.2 to 22.5 +/- 2.7 pmol/mg protein in 5 minutes. Increases in ...read more

Mentioned in this Paper

Methylnitronitrosoguanidine
Taenia Coli
Structure of Intestinal Gland
Guanylate Cyclase
Cyclic GMP
Liver

Similar Papers Found In These Feeds

sGC Modulators

Soluble guanylate cyclase (sGC) stimulators and activators have been developed to treat patients with pulmonary hypertension and heart failure, respectively. Recently these sGC modulators have been explored for the treatment of fibrosis. Discover the latest research on sGC modulators here.

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DNA replication in isolated nuclei. The fate of pulse-labelled DNA subunits

Experimental Cell ResearchSeptember 1, 1975
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Paper Details
References
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12
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