Abstract
Ursodeoxycholate, used to treat a variety of pathologies, has the ability to reverse cytotoxic and hepatotoxic conditions. We examined HepG2, a hepatic cell line, treated with increasing levels of ursodeoxycholate, for responses of a range of promoters/response elements responsive to DNA damage, heavy metal ions, protein denaturants, aromatic hydrocarbons, retinoids, changes in intracellular AMP levels, end endoplasmic reticulum stress. The metallothionein IIA promoter was the most highly activated by ursodeoxycholate. Since ursodeoxycholate protects against the cytotoxic effects of deoxycholate, our data, combined with observations made by others, implicate metallothionein IIA as being important in this protective pathway.
Citations
Jun 4, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiaofang HuoRhonda F Souza
Apr 11, 2009·World Journal of Gastroenterology : WJG·Maria-J Perez, Oscar Briz
Nov 13, 2012·Clinics and Research in Hepatology and Gastroenterology·Raoul Poupon
Oct 5, 2006·International Journal of Cancer. Journal International Du Cancer·Gui-Shan XiaoJianyu Rao
Jun 25, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A GoldmanK Dvorak
Sep 15, 2004·Toxicology·Carlos M Palmeira, Anabela P Rolo
Aug 23, 2011·Clinical Science·Marcelo G RomaEnrique J Sánchez Pozzi
Dec 15, 2010·Journal of Hepatology·Vlad RatziuUNKNOWN FRESGUN
Aug 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Elias Kouroumalis, George Notas
Nov 24, 2019·Cells·Magdalena Kusaczuk
Oct 3, 2003·The Journal of Biological Chemistry·Gary Guishan XiaoAndre E Nel
Sep 18, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Mohamed M Abdel-LatifJohn V Reynolds
Jan 5, 2006·The Biochemical Journal·Sonia Fernández-VeledoMarçal Pastor-Anglada
Jun 21, 2017·Scientific Reports·Jagadeesh Kumar UppalaKolluru V A Ramaiah
Mar 30, 2021·World Journal of Gastroenterology : WJG·Maria NadinskaiaElena Zueva