PMID: 7012603Nov 1, 1980Paper

Activation of the mutagens of beef extract in vitro and in vivo

Mutation Research
P DolaraD Benetti

Abstract

The activation in vitro of the mutagens isolated from beef extract, when tested with Salmonella typhimurium strain TA1538, requires the presence of S9 fractions from livers of PCB- or 3-methylcholanthrene-induced rats. S9 fractions from uninduced rats were unable to activate the mutagens, but no induction was necessary with Swiss albino mice. CD-1 mice had intermediate activation capabilities, which increased after the addition of 0.75% BHA to their diet. Human S9 were poor activators. No activation was observed with the whole homogenates. The active metabolites formed were unstable at 37 degrees C and firmly bound to protein. When isolated livers were perfused for activation, no inherently active mutagens were released into the perfusate. Similarly, no active mutagens were found in the urine of mice after administration to them of beef extract mutagens p.o. or i.p. Intrasanguine host-mediated assay did not show any significant mutagenic effect. The possibility that genotoxic effects of these compounds might be confined to metabolically competent cells of induced animals is discussed.

Citations

Jun 1, 1984·Mutation Research·J S Felton, S K Healy
Oct 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G CaderniP Dolara
Jun 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S AlbertiniF E Würgler
Nov 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M AlinkJ H Koeman
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Y IshidaR H Adamson
Aug 1, 1986·Environmental Health Perspectives·F J deSerresF T Hatch
Apr 1, 1983·Equine Veterinary Journal·D H Leach, A I Dagg
Feb 18, 1998·Zentralblatt für Veterinärmedizin. Reihe A·A GabrielC Bernard
Nov 19, 2011·Veterinary Surgery : VS·Eric EverettRaffaella DeVita
Apr 8, 2014·Veterinary Surgery : VS·Elizabeth J BarrettRobert L Jackson
Feb 1, 2013·Journal of Biomechanical Engineering·Jaclyn KondratkoRay Vanderby
Jan 1, 1985·Environmental Mutagenesis·L L Vuolo, G J Schuessler

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