Activation of the phosphatidylinositol 3-kinase/Akt pathway by viral interferon regulatory factor 2 of Kaposi's sarcoma-associated herpesvirus

Biochemical and Biophysical Research Communications
Yejin KimT Seo

Abstract

Kaposi's sarcoma-associated herpesvirus encodes several genes with sequence homology to cellular interferon regulatory factors. Among these, vIRF2 encoded by ORF K11.1 (short form) or K11 (full-length) participates in caspase-3-mediated inactivation of cellular IRF3 and slightly inhibits caspase-3 activity. Here, we have demonstrated that vIRF2 attenuates the transcriptional activity of forkhead box O3A protein via activation of the PI3K/Akt phosphatidylinositol 3-kinase/Akt pathway, inhibiting FOXO3A-mediated caspase-3 cleavage. Based on the collective findings, we suggest that vIRF2 acts as an activator in PI3K/Akt pathway.

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Citations

Apr 30, 2017·Biological Chemistry·Sandra Koch, Thomas F Schulz
Jul 1, 2020·Virus Research·Anna Bojagora, Vivian Saridakis

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