Activation of the platelet collagen receptor integrin alpha(2)beta(1): its mechanism and participation in the physiological functions of platelets

Trends in Cardiovascular Medicine
S M Jung, M Moroi

Abstract

When platelets are stimulated by agonists, integrin alpha(2)beta(1) (GP Ia/IIa), one of the platelet collagen receptors, is activated to forms with high affinities for its ligand collagen. Here we describe our studies to characterize the binding kinetics of the activated integrin forms and the activation mechanism. Under low agonist concentrations, integrin alpha(2)beta(1) is activated through a mechanism involving ADP/ADP receptors; and under high agonist concentrations, multiple signaling pathways are involved in its activation. Such differences in mechanism at low and high agonist concentrations are also suggested in the activation of integrin alpha(IIb)beta(3), the platelet fibrinogen receptor. We describe our flow adhesion studies, from which evidence was obtained about the involvement of integrin alpha(2)beta(1) activation in the physiological function of platelets, adhesion and thrombus formation.

References

Apr 1, 1991·The Journal of Clinical Investigation·Y IkedaI Itagaki
Nov 14, 1997·The Journal of Biological Chemistry·J EmsleyR C Liddington
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Jin, S P Kunapuli
Dec 3, 1999·European Journal of Clinical Investigation·L Alberio, G L Dale
Apr 18, 2009·Cell Adhesion & Migration·Joseph H McCarty

❮ Previous
Next ❯

Citations

Apr 7, 2012·Annals of Biomedical Engineering·Weiwei Wang, Michael R King
Jul 16, 2013·Journal of Computational Physics·Weiwei WangMichael R King
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·S S AhmadP N Walsh
Apr 26, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mubeen JafriGreg Tiao
Oct 15, 2014·Antioxidants & Redox Signaling·Ronit Mor-Cohen
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·S Ilveskero, R Lassila
Jun 1, 2006·The Journal of Pharmacy and Pharmacology·Sung Dae KimMan Hee Rhee
Nov 6, 2008·Journal of Thrombosis and Haemostasis : JTH·W RobertsK M Naseem
Jun 3, 2008·Journal of Thrombosis and Haemostasis : JTH·J M E M CosemansJ W M Heemskerk
Jun 24, 2004·Vox Sanguinis·H DeckmynK Vanhoorelbeke
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Robert Goggs, Alastair W Poole
Apr 29, 2011·Toxicon : Official Journal of the International Society on Toxinology·Alexey NavdaevJohannes A Eble
Apr 29, 2015·PloS One·Matthew F KeeYongzhi Qiu
Apr 20, 2017·International Journal of Molecular Sciences·Filippo MolicaBrenda R Kwak
Sep 4, 2004·The Journal of Biological Chemistry·Pia R-M SiljanderRichard W Farndale
Jun 12, 2004·Neurosurgical Focus·Richard M Lehman
Jul 26, 2005·Trends in Cardiovascular Medicine·Johan W M HeemskerkPia R M Siljander

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.