Activation of the prefrontal cortex during the Wisconsin Card Sorting Test as measured by multichannel near-infrared spectroscopy

Neuropsychobiology
Satsuki SumitaniTetsuro Ohmori

Abstract

The Wisconsin Card Sorting Test (WCST) is a neuropsychological test to evaluate the function of the prefrontal cortex (PFC). However, inconsistent results have been reported concerning whether this task activates the PFC symmetrically or asymmetrically. To investigate the brain activation in the PFC during the WCST, we examined blood oxygenation changes of healthy subjects by using multichannel near-infrared spectroscopy (NIRS). Subjects were 32 healthy volunteers, 18 males and 14 females. The WCST was administered using a computerized version, and the hemodynamic changes of the PFC during the WCST were measured by a 24-channel NIRS system. A bilateral increase in oxygenated hemoglobin (oxyHb) was observed in the PFC in 20 subjects during the WCST. However, 5 subjects showed predominant activation on the left side and 3 subjects one on the right side. No oxyHb change was observed in 4 subjects, although they had good performances in the WCST. These results directly confirmed that the PFC was activated during the WCST in vivo by using the optical technique and suggested that the distribution of the activation in the PFC is different among healthy individuals.

References

Dec 1, 1976·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·H E Nelson
Jan 1, 1995·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·J P Davies, W H Harris
Oct 1, 1996·Brain : a Journal of Neurology·Y NagahamaJ Kimura
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M TamuraF Okada
Dec 5, 1998·European Archives of Psychiatry and Clinical Neuroscience·A J Fallgatter, W K Strik
Apr 9, 1999·Nature Neuroscience·S KonishiY Miyashita
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Seiki KonishiYasushi Miyashita

❮ Previous
Next ❯

Citations

Apr 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yusuke Moriguchi, Kazuo Hiraki
Mar 24, 2012·Journal of Personality Assessment·Hirotoshi HiraishiHideo Matsumoto
Nov 15, 2011·Applied Neuropsychology·Masaru ShoyamaKazuhiro Shinosaki
Dec 18, 2007·Psychiatry and Clinical Neurosciences·Sumiko Shibuya-TayoshiTetsuro Ohmori
Jun 17, 2010·Journal of Physiological Anthropology·Katsuo FujiwaraXingyun Deng
Mar 23, 2012·Developmental Cognitive Neuroscience·Yusuke Moriguchi, Kazuo Hiraki
Jul 29, 2015·Physiological Reports·Nuno S DiasNuno Sousa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.