Activation of the reaper gene during ectopic cell killing in Drosophila

Developmental Biology
W NordstromJ M Abrams

Abstract

The product of the reaper (rpr) gene is required for programmed cell death in Drosophila. We examined rpr expression during ectopic cell deaths caused by ionizing radiation or aberrant development. In both instances, dramatic induction of rpr expression was observed. A genomic fragment upstream of rpr confers this regulatory behavior upon a lacZ reporter transgene. In a model cell culture system, conditional expression of REAPER is sufficient to induce massive apoptosis that can be prevented by the anti-apoptotic protein p35. Overall, these results suggest that diverse signals converge at, or upstream of, rpr-associated transcriptional regulatory elements that can function to initiate a common apoptotic pathway involving ICE-like protease activity.

Citations

Dec 2, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N M Bonini, M E Fortini
Aug 28, 2013·Apoptosis : an International Journal on Programmed Cell Death·Sol FereresAna Busturia
May 6, 2003·Biochemical and Biophysical Research Communications·Cristina Clavería, Miguel Torres
Jun 20, 2002·Journal of Immunological Methods·Helena Richardson, Sharad Kumar
Jun 1, 1997·Trends in Genetics : TIG·K McCall, H Steller
Oct 8, 1999·Trends in Cell Biology·J M Abrams
Apr 26, 2008·Cell Death and Differentiation·H Steller
Aug 17, 2011·Cell Research·Xianjue MaLei Xue
Oct 14, 2000·Cell Research·C Y Lee, E H Baehrecke
Oct 10, 2006·Oncogene·M Jovanovic, M O Hengartner
Dec 19, 1998·The EMBO Journal·C ClaveríaM Torres
Jul 3, 2002·The EMBO Journal·Cristina ClaveríaMiguel Torres
May 10, 2005·Genes & Development·Jill WildongerRichard S Mann
Dec 6, 2008·Genes & Development·Sonam MehrotraBrian R Calvi
Sep 19, 2006·Molecular and Cellular Biology·Shu KondoMasayuki Miura
Jan 20, 2004·Molecular and Cellular Biology·Michael H BrodskyGerald M Rubin
Apr 29, 1998·Annual Review of Physiology·V J Kidd
Feb 24, 2001·Genome Biology·J N Tittel, H Steller
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·T KondoS Nagata
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·M MilánA García-Bellido
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·D VucicL K Miller
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·S JinA J Levine
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·V AvdoninL Iverson
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Naoko SogameJohn M Abrams
Apr 12, 2006·The Journal of Cell Biology·Usha AcharyaJairaj K Acharya
Mar 20, 2002·The Journal of Cell Biology·Katja C ZimmermannDouglas R Green
Feb 26, 1999·The Journal of Cell Biology·J VarkeyJ M Abrams
Dec 19, 2015·Apoptosis : an International Journal on Programmed Cell Death·Amandine ClavierIsabelle Guénal
Jul 14, 2012·International Journal of Radiation Biology·Federico H GomezFabian M Norry
Oct 17, 2015·PLoS Genetics·Chenxi WuLei Xue
Oct 27, 1999·Mechanisms of Development·S Chao, R N Nagoshi
Oct 24, 1998·The Journal of Biological Chemistry·R BoseR N Kolesnick
Nov 26, 2002·The Journal of Biological Chemistry·Michael R OlsonSally Kornbluth
Jun 15, 2000·Nature Cell Biology·H Steller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis