Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice.

Circulation Research
De-xiu BuA M Schmidt

Abstract

The multiligand RAGE (receptor for advanced glycation end products) contributes to atherosclerosis in apolipoprotein (Apo)E-null mice. To delineate the specific mechanisms by which RAGE accelerated atherosclerosis, we performed Affymetrix gene expression arrays on aortas of nondiabetic and diabetic ApoE-null mice expressing RAGE or devoid of RAGE at nine weeks of age, as this reflected a time point at which frank atherosclerotic lesions were not yet present, but that we would be able to identify the genes likely involved in diabetes- and RAGE-dependent atherogenesis. We report that there is very little overlap of the genes that are differentially expressed both in the onset of diabetes in ApoE-null mice, and in the effect of RAGE deletion in diabetic ApoE-null mice. Pathway-Express analysis revealed that the transforming growth factor-beta pathway and focal adhesion pathways might be expected to play a significant role in both the mechanism by which diabetes facilitates the formation of atherosclerotic plaques in ApoE-null mice, and the mechanism by which deletion of RAGE ameliorates this effect. Quantitative polymerase chain reaction studies, Western blotting, and confocal microscopy in aortic tissue and in primary cultures of...Continue Reading

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Citations

Oct 20, 2010·Amino Acids·Ravichandran RamasamyAnn Marie Schmidt
Mar 30, 2012·Current Heart Failure Reports·Ravichandran Ramasamy, Ann Marie Schmidt
Dec 5, 2012·The Journal of Experimental Medicine·Vivek RaiAnn Marie Schmidt
Oct 23, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Marion A Hofmann BowmanElizabeth M McNally
Jan 19, 2012·Cardiovascular Diabetology·Jiping WangQiaobing Huang
Feb 14, 2013·Heart Failure Reviews·Vijaya Lakshmi BodigaSreedhar Bodiga
Aug 9, 2015·Diabetes·Gurdip DaffuAnn Marie Schmidt
Apr 5, 2011·Clinical Science·Drazenka Pongrac BarlovicKarin A M Jandeleit-Dahm
Jul 11, 2013·Cellular Signalling·Jianling XieMaría Montserrat Aguilar-Hernández
May 31, 2018·Toxins·Lucie HénautZiad A Massy
Jun 15, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Linghua KongShi Fang Yan
Mar 7, 2012·Expert Review of Cardiovascular Therapy·Christine KoulisTerri J Allen
Oct 17, 2014·International Journal of Molecular Medicine·Min LinJing Weng
May 7, 2020·American Journal of Physiology. Cell Physiology·Jeffrey S Isenberg, David D Roberts
Feb 23, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Ann Marie Schmidt
Sep 17, 2020·Critical Reviews in Biochemistry and Molecular Biology·Nitish JangdeVivek Rai
May 15, 2015·Clinical Pharmacology and Therapeutics·Ems LitwinoffA M Schmidt
Jul 18, 2018·Frontiers in Cardiovascular Medicine·Anindita DasFadi N Salloum
Oct 4, 2017·Frontiers in Pharmacology·Suowen Xu
Jul 1, 2020·Cellular and Molecular Life Sciences : CMLS·Madeline Nieves-CintrónManuel F Navedo
Nov 13, 2015·Expert Opinion on Therapeutic Targets·Ravichandran RamasamyAnn Marie Schmidt
Jan 4, 2012·Annals of the New York Academy of Sciences·Ravichandran RamasamyAnn Marie Schmidt
Oct 7, 2020·International Journal of Molecular Sciences·Adriana Machado-LimaMarisa Passarelli
Jul 3, 2021·International Journal of Molecular Sciences·Hyeon Jin KimSe Bok Jang

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