Activation of the skeletal muscle Ca2+ release channel by the triazine dyes cibacron blue F3A-G and reactive red 120.

Archives of Biochemistry and Biophysics
L XuG Meissner

Abstract

Vesicle-45Ca2+ ion flux and planar lipid bilayer single-channel measurements have shown that the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (SR) is activated by micromolar concentrations of Cibacron Blue F3A-G (Reactive Blue 2) and Reactive Red 120. Cibacron Blue increased the 45Ca2+ efflux rate from heavy SR vesicles by apparently interacting with both the adenine nucleotide and caffeine activating sites of the channel. Dye-induced 45Ca2+ release was inhibited by Mg2+ and ruthenium red. In single channel recordings with the purified channel protein complex, Cibacron Blue increased the open time of the Ca2+ release channel without an apparent change in the conductance of the main and subconductance states of the channel.

References

Jan 1, 1977·Physiological Reviews·M Endo
Sep 1, 1987·The American Journal of Physiology·E RousseauG Meissner
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L HymelH Schindler
Jun 1, 1988·Archives of Biochemistry and Biophysics·J J AbramsonG Salama
Jul 1, 1988·The Journal of Cell Biology·A SaitoS Fleischer
Jul 1, 1988·Cell·P A Lawrence
Oct 1, 1986·The Journal of Cell Biology·R M KawamotoA H Caswell
Jan 1, 1981·The American Journal of Physiology·E W Stephenson
Jan 1, 1983·Molecular and Cellular Biochemistry·G Meissner
Jul 1, 1983·The American Journal of Physiology·A Fabiato
Sep 17, 2013·Transfusion·Jay S EpsteinHarvey G Klein

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Citations

Mar 1, 1994·Journal of Applied Toxicology : JAT·D F Muldoon, S J Stohs
Sep 1, 1995·Molecular Reproduction and Development·P K Schoff, N L First
Jul 22, 2004·British Journal of Pharmacology·Richard A BillingtonArmando A Genazzani

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