Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist

Oncology Letters
Xiaohong Sun, Yu Liu

Abstract

The Wnt signaling pathway regulates a number of biological processes. In the present study, the association between the Wnt signaling pathway and the pathogenesis of cervical cancer was investigated in the human cervical cancer CaSki cell line. An MTT assay was used to screen various concentrations of lithium chloride for use in subsequent experiments. Following incubation of CaSki cells with 0.05 and 0.1 mol/l lithium chloride, Twist and β-catenin were markedly upregulated at the mRNA and protein levels, respectively, compared with the untreated group, as measured by reverse transcription-polymerase chain reaction and western blotting. The results of the present study indicate that Wnt activation (which was induced by lithium chloride) and the subsequent upregulation of Twist may represent one of the molecular mechanisms underlying the occurrence and development of cervical cancer.

References

Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S Klein, D A Melton
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
Jun 23, 2005·World Journal of Surgical Oncology·Oluwole FadareWenxin Zheng
Sep 5, 2006·Vaccine·D Maxwell Parkin, Freddie Bray
Jul 9, 2008·International Archives of Medicine·Carlos Perez-PlasenciaBrenda Alatorre-Tavera
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Jun 17, 2011·Journal of Cellular Biochemistry·Akihiko HiyamaJoji Mochida
Jul 1, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Ying Ying, Qian Tao
Mar 17, 2017·Journal of Cellular Biochemistry·Afsane BahramiAmir Avan

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Citations

Jun 6, 2020·Reproduction in Domestic Animals = Zuchthygiene·Lina HeZhongquan Zhao
Nov 30, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Shuxiang XuXu Chen
Sep 9, 2020·Journal of Receptor and Signal Transduction Research·Xiao-Ying JiangLan Xi
Nov 7, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nithidol Sakunrangsit, Wannarasmi Ketchart
Aug 4, 2021·The Journal of Obstetrics and Gynaecology Research·Mengyue ChenLimei Zhao

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