PMID: 3748315Jun 1, 1986Paper

Activation of thermogenesis of brown fat in rats by baclofen

Neuropharmacology
J I AddaeT W Stone

Abstract

Injection of baclofen (0.5-5 micrograms) into the ventromedial hypothalamus (VMH) of anaesthetized rats produced marked increases in the temperature (over 2 degrees C) and thermogenic activity of brown adipose tissue (BAT). These effects were abolished by ganglionic or beta-adrenergic blockade, or denervation of the tissue, but unaffected by hypophysectomy, adrenalectomy or vagotomy. Injections into the hypothalamus close to, but outside the ventromedial hypothalamus did not affect brown adipose tissue. Intravenous administration of baclofen produced similar increases in the temperature of brown adipose tissue, but at larger doses (50-1000 micrograms), and a subcutaneous injection stimulated the metabolic rate in conscious rats. Chronic treatment with baclofen suppressed weight gain and stimulated activity of brown adipose tissue without affecting food intake. These effects of baclofen, which were not mimicked by injections of gamma-aminobutyric acid (GABA), indicate a novel action of baclofen in the ventromedial hypothalamus, leading to marked increases in metabolic rate and body temperature by stimulating sympathetic outflow to brown fat.

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Citations

Jan 1, 1989·Journal of Neural Transmission. General Section·C González SolveyraD P Cardinali
Jul 1, 1989·Brain Research. Brain Research Reviews·R R Matsumoto
Apr 4, 2002·Drugs·José-Antonio Fernández-LópezMarià Alemany
Sep 13, 2003·British Journal of Pharmacology·Christophe QuévaJan P Mattsson
Jun 1, 1992·Metabolism: Clinical and Experimental·L BreumJ Madsen
Apr 4, 2006·Autonomic Neuroscience : Basic & Clinical·Joseph A DiMiccoDmitry V Zaretsky
Dec 20, 2005·Pharmacology, Biochemistry, and Behavior·Richard W Foltin
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·R G Paredes, A Agmo
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·K NagashimaK Kanosue
Apr 5, 2007·Pharmacology, Biochemistry, and Behavior·Bruce E Hetzler, Janie M Ondracek

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