Activation of thymic B cells by signals of CD40 molecules plus interleukin-10

European Journal of Immunology
M InabaH Hisha

Abstract

We have previously found that thymic B cells, particularly thymic CD5+ B cells, show low responsiveness to the usual B cell stimulants such as lipopolysaccharide or anti-IgM plus interleukin (IL)-4, although they proliferate and produce antibodies after direct interaction with major histocompatibility complex class II-restricted T blasts. These findings raise the possibility that a CD40-CD40 ligand (L) interaction is involved in the activation of thymic B cells. In the present study, we therefore examine this possibility using CD40L-transfected Chinese hamster ovary (CHO) cells or anti-CD40 monoclonal antibody (mAb). When B cells in the spleen and peritoneal cavity were stimulated, they proliferated and produced immunoglobulin (Ig) in the presence of CD40L-CHO cells or anti-CD40 mAb alone. However, another signal delivered by IL-10 in addition to CD40L-CHO cells or anti-CD40 mAb was found to be necessary for thymic B cells to proliferate and secrete Ig. Other interleukins acting on B cells, such as IL-4, IL-5, and IL-6, had no effect on the activation of thymic B cells, which thus have unique characteristics not found in peripheral B cells. This report discusses the physiological significance of IL-10- and CD40-driven signals i...Continue Reading

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Citations

Nov 7, 1996·The New England Journal of Medicine·A P KourtisS Nesheim
Jul 5, 2001·Journal of Autoimmunity·N TaguchiM E Gershwin
Apr 4, 2015·Cellular and Molecular Life Sciences : CMLS·Jason Perera, Haochu Huang
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judie BoisvertMatthew F Krummel
Sep 26, 2017·Médecine sciences : M/S·Vincent GiesAnne-Sophie Korganow
Aug 5, 2017·The Journal of Experimental Medicine·Masashi WatanabeRichard J Hodes
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kikumi HataJunichiro Mizuguchi
Jul 17, 1999·The American Journal of Physiology·K ImaizumiY Hasegawa
Nov 28, 2000·European Journal of Immunology·L MajlessiG Bordenave

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