Activation of Toll-like receptor 3 induces apoptosis of oral squamous carcinoma cells in vitro and in vivo

The International Journal of Biochemistry & Cell Biology
Qingqiong LuoFuxiang Chen

Abstract

Toll-like receptors are well known as molecular sensors of pathogen-associated molecular patterns. They control activation of the innate immune response and subsequently shape the adaptive immune response. Recent publications have demonstrated that Toll-like receptors also play important roles in multiple human cancers, yet their function in oral squamous cell carcinoma remains unclear. In this study, we showed that both oral squamous cell carcinoma cell lines and tissues from oral squamous carcinoma patients express relatively high levels of Toll-like receptor 3. We also found that synthetic dsRNA-polyinosinic-polycytidilic acid, a Toll-like receptor 3 ligand, induced apoptosis of oral squamous carcinoma cells mainly via Toll-like receptor 3, through interferon-β production and activation of caspases 3 and 9. Moreover, in an oral squamous cell carcinoma xenograft mouse model, we demonstrated for the first time that activation of Toll-like receptor 3 inhibited oral squamous cell carcinoma tumor growth in vivo. Therefore, the direct proapoptotic activity of Toll-like receptor 3 in human oral squamous carcinoma cells may make this protein a viable therapeutic target in the treatment of oral squamous cell carcinoma.

References

Apr 1, 1995·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A L KhanO Eremin
Mar 22, 2002·The Lancet Oncology·C Scully, R Bedi
May 18, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shin-Hun JuangWen K Yang
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Feb 16, 2005·Nature·Oliver SchulzCaetano Reis e Sousa
Jan 21, 2006·Nature Immunology·Taro Kawai, Shizuo Akira
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
May 4, 2006·Journal of the National Cancer Institute·Charlie Schmidt
Jun 10, 2006·Nature Reviews. Drug Discovery·Arthur M Krieg
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bruno SalaunPedro Romero
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Teppei MorikawaHiroyuki Aburatani
Nov 28, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joari De MirandaW Ian Lipkin
Dec 17, 2008·Annals of the New York Academy of Sciences·Taro Kawai, Shizuo Akira
Feb 3, 2009·Cancer Immunology, Immunotherapy : CII·Mingfu ZhouAngela F Drew
Mar 3, 2009·Oral Oncology·Crispian Scully, Jose Bagan
Dec 10, 2009·The Journal of Experimental Medicine·Stephen McCartneyMarco Colonna
Apr 30, 2010·Cellular Immunology·Sandra WulffBarbara Wollenberg
Oct 28, 2010·Cancer Immunology, Immunotherapy : CII·Salomé González-ReyesFrancisco J Vizoso
Dec 7, 2010·BMC Cancer·Salomé González-ReyesFrancisco J Vizoso
Dec 30, 2010·Acta Odontologica Scandinavica·Riitta PahkalaJuha Seppä
Jan 15, 2011·Acta Odontologica Scandinavica·Deyar Jallal Hadi MahmoodPer Vult Von Steyern
Apr 2, 2011·International Journal of Molecular Medicine·Eun-Jung SongJong-Hwan Park
Jul 8, 2011·Clinical & Experimental Metastasis·Tanja Matijevic, Jasminka Pavelic
Nov 11, 2011·Oral Oncology·Hui-Ching ChuangJiin-Haur Chuang

❮ Previous
Next ❯

Citations

Sep 30, 2014·Oral Oncology·Laura K MäkinenJaana Hagström
Apr 2, 2016·Cancer Immunology, Immunotherapy : CII·Johanna C KleinSven Brandau
Oct 2, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Laura K MäkinenTimo Atula
Jul 18, 2015·Developmental and Comparative Immunology·Amanda L PatchettGregory M Woods
May 16, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·R LeonardiG Pannone
Oct 14, 2014·Frontiers in Immunology·Alison Mary RichGregory J Seymour
Jun 2, 2018·Journal of Immunology Research·Marconi Rego BarrosAntonio Carlos de Freitas
May 15, 2021·Frontiers in Immunology·Xin ZhengHui Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis