Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear

Aging Cell
Shyan-Yuan KaoKonstantina M Stankovic

Abstract

Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF-α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5-blocking antibodies.

References

Oct 4, 1984·The New England Journal of Medicine·P R DodgeS K Hirsh
Mar 19, 1993·Science·L M ObeidY A Hannun
Nov 5, 1997·Nature Genetics·G S WuW S el-Deiry
Jun 11, 1998·The Journal of Biological Chemistry·J G EmeryP R Young
Jul 13, 2000·Cell Death and Differentiation·U WendlingF Zipp
Nov 20, 2001·Endocrinology·S Khosla
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 26, 2003·Cell Death and Differentiation·H N LeBlanc, A Ashkenazi
Mar 9, 2004·Mechanisms of Development·Grace Lawoko-KeraliMatthew C Holley
Jan 24, 2006·Journal of Neuroscience Research·Masato FujiokaHideyuki Okano
Aug 23, 2006·Acta Oto-laryngologica·R BovoA Martini
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniela UbertiMaurizio Memo
Aug 31, 2006·Molecular and Cellular Biology·Zhaoyu Jin, Wafik S El-Deiry
Dec 29, 2007·The Journal of Pathology·J R Bradley
May 19, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Olaf HoffmannJoerg R Weber
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sharon G Kujawa, M Charles Liberman
May 31, 2011·Autoimmunity Reviews·A GrecoM De Vincentiis
Aug 4, 2011·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hee-Jeong CheongJae Ho Byun
Sep 23, 2011·Cellular and Molecular Neurobiology·Yanli NiuJinbo Deng
Jul 21, 2012·The Laryngoscope·Hun Yi ParkChul-Ho Kim
Feb 6, 2013·The Laryngoscope·Erhan DemirhanFatos Guldal Kirkali
Dec 25, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael PlattKonstantina M Stankovic

❮ Previous
Next ❯

Citations

Aug 9, 2016·The Laryngoscope·Mahyar EtminanBruce C Carleton
Apr 27, 2016·Developmental Neurobiology·Jane Bjerg GrothKonstantina M Stankovic
Mar 16, 2018·Cancer Metastasis Reviews·Xun YuanGen Sheng Wu
May 18, 2021·BioMed Research International·Umair MahmoodSaima Riazuddin

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
cochlear
Fluorescence
dissecting
dissection
confocal microscopy

Software Mentioned

ImageJ
Leica

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Zhonghua zhong liu za zhi [Chinese journal of oncology]
Yuan-Fang MaYou-hai Chen
American Journal of Respiratory and Critical Care Medicine
Mathieu C MorissetteJulie Milot
Biomedical and Environmental Sciences : BES
Gen-Hong YaoQian-hong Lei
© 2022 Meta ULC. All rights reserved