Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis

Molecular and Cellular Biology
Kathryn A O'DonnellChi V Dang

Abstract

Overexpression of transferrin receptor 1 (TFRC1), a major mediator of iron uptake in mammalian cells, is a common feature of human malignancies. Therapeutic strategies designed to interfere with tumor iron metabolism have targeted TFRC1. The c-Myc oncogenic transcription factor stimulates proliferation and growth by activating thousands of target genes. Here we demonstrate that TFRC1 is a critical downstream target of c-Myc. Using in vitro and in vivo models of B-cell lymphoma, we show that TFRC1 expression is activated by c-Myc. Chromatin immunoprecipitation experiments reveal that c-Myc directly binds a conserved region of TFRC1. In light of these findings, we sought to determine whether TFRC1 is required for c-Myc-mediated cellular proliferation and cell size control. TFRC1 inhibition decreases cellular proliferation and results in G1 arrest without affecting cell size. Consistent with these findings, expression profiling reveals that TFRC1 depletion alters expression of genes that regulate the cell cycle. Furthermore, enforced TFRC1 expression confers a growth advantage to cells and significantly enhances the rate of c-Myc-mediated tumor formation in vivo. These findings provide a molecular basis for increased TFRC1 express...Continue Reading

References

Jan 1, 1979·Journal of Supramolecular Structure·J W Larrick, P Cresswell
Jan 1, 1992·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·J D KempP W Naumann
Mar 1, 1991·American Journal of Hematology·W FeremansL Schandene
Jan 1, 1986·Cancer Investigation·L M Neckers, J B Trepel
May 1, 1987·Molecular and Cellular Biology·M B SmallJ M Bishop
May 1, 1987·European Journal of Pediatrics·J BlattP A Lee
May 1, 1983·Journal of Clinical Pathology·K C GatterD Y Mason
Sep 15, 1983·International Journal of Cancer. Journal International Du Cancer·R TaetleI Trowbridge
Sep 1, 1994·Molecular and Cellular Biology·K D HansonJ M Sedivy
Aug 1, 1996·Nuclear Medicine and Biology·R E Weiner
May 1, 1997·Trends in Biochemical Sciences·C Grandori, R N Eisenman
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·K E BoydP J Farnham
Dec 22, 1998·Molecular and Cellular Biology·C V Dang
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·B M Iritani, R N Eisenman
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·H A CollerT R Golub
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·A PajicD Eick
Aug 31, 2000·Cell·C J Sherr, R A DePinho
Jan 5, 2001·Nucleic Acids Research·M SchuhmacherD Eick
Oct 18, 2001·The Journal of Biological Chemistry·K I ZellerC V Dang
Mar 12, 2002·Advances in Cancer Research·Sara K OsterLinda Z Penn
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuJohn B Hogenesch
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Diane R WonseyChi V Dang
Jun 7, 2002·Critical Reviews in Oncology/hematology·D R Richardson
Jun 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Izidore S LossosRonald Levy
Aug 28, 2002·Biochemical Society Transactions·H BowenC H Barton
Oct 3, 2002·Nature Reviews. Cancer·Stella PelengarisGerard Evan
Jan 17, 2003·The Journal of Biological Chemistry·Brenda C O'ConnellJohn M Sedivy
Feb 8, 2003·Advances in Experimental Medicine and Biology·Des R Richardson
Apr 4, 2003·Oncogene·Sara K OsterLinda Z Penn
Apr 16, 2003·Genes & Development·Amir OrianRobert N Eisenman
Apr 16, 2003·Genes & Development·Paula C FernandezBruno Amati
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Timothy J HaggertyChi V Dang
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zirong LiBing Ren
Jul 4, 2003·The Journal of Biological Chemistry·Holly BowenC Howard Barton
Oct 2, 2003·Genome Biology·Douglas A HosackRichard A Lempicki
Oct 3, 2003·Cancer Cell·Katharine Ellwood-YenCharles L Sawyers

❮ Previous
Next ❯

Citations

Aug 14, 2012·Cell Reports·Sorina RadulescuOwen J Sansom
Dec 10, 2013·Inorganic Chemistry·Brian M ZeglisJason S Lewis
Dec 11, 2007·Nature Genetics·Tsung-Cheng ChangJoshua T Mendell
Sep 25, 2012·Nature Medicine·Jason P HollandJason S Lewis
Nov 30, 2007·Nature Reviews. Cancer·Chi V DangJason Yustein
Aug 19, 2007·Oncogene·M J BrookesC Tselepis
Jun 25, 2008·The Journal of Biological Chemistry·Michelle L WallanderElizabeth A Leibold
Mar 11, 2010·Antioxidants & Redox Signaling·Stefania RecalcatiGaetano Cairo
Mar 20, 2012·Antioxidants & Redox Signaling·Angelica M MerlotDes R Richardson
Nov 28, 2006·Carcinogenesis·Guohua ChenKostas Pantopoulos
May 24, 2012·Neuroreport·Robin E White, Rona G Giffard
Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J Y SongK W Lee
May 9, 2012·Molecular and Cellular Biology·Christopher J PangMarie Trudel
Jun 3, 2010·The Journal of Clinical Investigation·Shariq S KhwajaRichard J Bram
Feb 26, 2013·The Journal of Clinical Investigation·Shunsuke KonMasanobu Satake
Aug 30, 2008·Blood·Jeffrey S Friedman
Jan 9, 2007·PLoS Computational Biology·Neil KumarDouglas A Lauffenburger
Dec 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael J EvansJason S Lewis
Jul 3, 2013·Nutrients·Xiang Xue, Yatrik M Shah
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jonathan R HartKim D Janda
Dec 17, 2014·Journal of the National Cancer Institute·Austin N KirschnerSarki A Abdulkadir
Feb 13, 2016·Biochemical and Biophysical Research Communications·Seung Min JeongRho Hyun Seong
Jul 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yoshiaki TabuchiTakashi Kondo
Jun 14, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Erick RiquelmeIgnacio I Wistuba
Aug 22, 2014·Journal of Translational Medicine·Jiandong WangChunxiao Zhou
Dec 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Marissa RashkovanTarik Möröy
Mar 20, 2013·Molecular Aspects of Medicine·Nicolas MontalbettiMatthias A Hediger
Oct 11, 2011·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·F Aleixandre BlanquerF Galán Sánchez
Jan 6, 2016·Nature Communications·Laia RichartFrancisco X Real
May 27, 2008·European Urology·Thorsten SchlommHolger Sültmann
May 20, 2008·Biochimica Et Biophysica Acta·D R RichardsonD B Lovejoy
Sep 8, 2007·Biochemical and Biophysical Research Communications·Faizan Alawi, Megan N Lee
Apr 13, 2007·Blood Cells, Molecules & Diseases·Alessia CalzolariUgo Testa

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