Activation of transforming growth factor-beta1 and early atherosclerosis in systemic lupus erythematosus.

Arthritis Research & Therapy
Michelle JacksonPaul E C Brenchley

Abstract

The efficiency of activating latent transforming growth factor (TGF)-beta1 in systemic lupus erythematosus (SLE) may control the balance between inflammation and fibrosis, modulating the disease phenotype. To test this hypothesis we studied the ability to activate TGF-beta1 in SLE patients and control individuals within the context of inflammatory disease activity, cumulative organ damage and early atherosclerosis. An Activation Index (AI) for TGF-beta1 was determined for 32 patients with SLE and 33 age-matched and sex-matched control individuals by quantifying the increase in active TGF-beta1 under controlled standard conditions. Apoptosis in peripheral blood mononuclear cells was determined by fluorescence-activated cell sorting. Carotid artery intima-media thickness was measured using standard Doppler ultrasound. These measures were compared between patients and control individuals. In an analysis conducted in patients, we assessed the associations of these measures with SLE phenotype, including early atherosclerosis. Both intima-media thickness and TGF-beta1 AI for SLE patients were within the normal range. There was a significant inverse association between TGF-beta1 AI and levels of apoptosis in peripheral blood mononucle...Continue Reading

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Citations

Aug 26, 2010·Nature Reviews. Rheumatology·Clare TowerIan Bruce
Feb 15, 2012·Nature Reviews. Rheumatology·Brian J SkaggsMaureen McMahon
Jul 20, 2007·Arthritis Research & Therapy·Arne HansenThomas Dörner
Oct 3, 2012·Vascular Health and Risk Management·Santiago RedondoTeresa Tejerina
Feb 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Pascal N TyrrellTimothy J Bradley
Nov 17, 2015·The Journal of Rheumatology·Konstantinos TseliosMurray B Urowitz
Nov 7, 2008·Clinical Reviews in Allergy & Immunology·Paul R J AmesJose Delgado Alves
Nov 21, 2008·Pathology Oncology Research : POR·Eszter KohutAnna Sebestyén
Jul 1, 2007·Expert Review of Clinical Immunology·Elena Bartoloni BocciRoberto Gerli
Feb 13, 2013·American Journal of Reproductive Immunology : AJRI·Clare TowerIan N Bruce
Feb 13, 2018·Frontiers in Medicine·Vítor Teixeira, Lai-Shan Tam
Apr 15, 2010·Rheumatology International·Armen Yuri GasparyanGeorge D Kitas

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Methods Mentioned

BETA
ELISAs
ELISA
flow cytometry

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