Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats

Neuroreport
Atsufumi KawabataAkiko Ogawa

Abstract

To clarify involvement of protease-activated receptor-2 (PAR-2) in parotid pain, we examined whether PAR-2 activation in the parotid gland could activate trigeminal nociceptive neurons in anesthetized rats, by analyzing immunoreactive Fos as a nociceptive marker. Either the PAR-2 agonist SLIGRL-NH2 or capsaicin, injected into the parotid duct, caused expression of Fos in the trigeminal subnucleus caudalis, although the PAR-2-inactive reversed peptide had no such effect. The Fos expression caused by PAR-2 activation was inhibited by ablation of capsaicin-sensitive sensory neurons. Intraductal SLIGRL-NH2 did not increase vascular permeability in the parotid gland. Our data thus reveal that activation of PAR-2 in the parotid gland can cause activation of trigeminal nociceptive neurons via capsaicin-sensitive sensory nerves most probably by a non-inflammatory mechanism.

References

Jun 8, 2001·The Journal of Clinical Investigation·A KawabataK Kakehi
Jul 4, 2001·Nature Medicine·N VergnolleJ L Wallace
Aug 25, 2001·Naunyn-Schmiedeberg's Archives of Pharmacology·A KawabataH Araki
Mar 6, 2002·British Journal of Pharmacology·Samuel AsfahaNathalie Vergnolle
Apr 4, 2002·Neuroreport·Atsufumi KawabataHiroyuki Nishikawa
Jul 18, 2002·Japanese Journal of Pharmacology·Naoyuki KawaoAtsufumi Kawabata
Jul 20, 2002·Peptides·Atsufumi KawabataChiho Shimada
Dec 20, 2003·Nature Reviews. Neuroscience·Farshid NoorbakhshChristopher Power
Mar 24, 2004·Journal of Pharmacological Sciences·Naoyuki KawaoAtsufumi Kawabata
Mar 27, 2004·Physiological Reviews·Valeria S Ossovskaya, Nigel W Bunnett

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Citations

Feb 13, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·James D Moffatt
Apr 17, 2007·Life Sciences·Hiroyasu IshikuraAtsufumi Kawabata
Nov 13, 2007·British Journal of Pharmacology·A KawabataF Sekiguchi
Dec 21, 2005·Experimental Dermatology·Otilia ObrejaMartin Schmelz
Sep 1, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Atsufumi Kawabata
May 3, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Atsufumi Kawabata
Nov 21, 2019·Journal of Dental Research·K Iwata, B J Sessle

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