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Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia

Biochemical and Biophysical Research Communications

Nov 14, 2019

Jun-Ho ChoJanice Yang Chou

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Abstract

Hepatocellular adenoma/carcinoma (HCA/HCC) is a long-term complication of the metabolic disorder glycogen storage disease type Ia (GSD-Ia) deficient in glucose-6-phosphatase-α (G6PC or G6Pase-α). We have shown previously that hepatic G6Pase-α deficiency leads to autophagy impairment, mi...read more

Mentioned in this Paper

Autophagy
Complication
GLUCOSE-6-PHOSPHATASE
Glucosephosphate Isomerase
Glycogen
Glycolysis
Hepatitis
Liver
Oncogenes
Phosphorylation
1
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Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia

Biochemical and Biophysical Research Communications

Nov 14, 2019

Jun-Ho ChoJanice Yang Chou

PMID: 31735334

DOI: 10.1016/j.bbrc.2019.11.061

Abstract

Hepatocellular adenoma/carcinoma (HCA/HCC) is a long-term complication of the metabolic disorder glycogen storage disease type Ia (GSD-Ia) deficient in glucose-6-phosphatase-α (G6PC or G6Pase-α). We have shown previously that hepatic G6Pase-α deficiency leads to autophagy impairment, mi...read more

Mentioned in this Paper

Autophagy
Complication
GLUCOSE-6-PHOSPHATASE
Glucosephosphate Isomerase
Glycogen
1

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