Activation of two sites by adenosine receptor agonists to cause relaxation in rat isolated mesenteric artery

British Journal of Pharmacology
D J PrenticeS M Hourani

Abstract

1. In this study we have characterized the receptor(s) in the rat mesenteric artery mediating relaxant responses to adenosine and a number of adenosine analogues, N6-R-phenylisopropyladenosine (R-PIA), N6-cyclopentyladenosine (CPA), N6-(3-iodo-benzyl)-adenosine-5'-N-methyluronamide (IB-MECA) and 5'-N-ethylcarboxamidoadenosine (NECA), by use of the non-selective antagonist 8-sulphophenyltheophylline (8-SPT) and the A2A selective ligands 2-[p-(2-carbonylethyl)-phenylethylamino]-5'-N-ethylcarboxami doadenosine (CGS 21680) and 4-(2-[7-amino-2-(2-furyl)[1,2,4]-triazolo[2,3-a][1,3,5]-triazin-5- ylamino]ethyl) phenol (ZM 241385). We have also studied the effects of endothelial removal and uptake inhibition by nitrobenzylthioinosine (NBTI) and the effects of the A3 receptor antagonist 1,3-dipropyl-8-(4-acrylate)phenylxanthine (BWA1433). 2. Adenosine, NECA, CPA and R-PIA all elicited relaxant responses in tissues precontracted with phenylephrine (1 microM) with the following potency order: NECA > R-PIA > adenosine = CPA. However, E/[A] curves to NECA were biphasic. CGS 21680 was inactive at concentrations up to 30 microM and IB-MECA elicited relaxant responses which were resistant to blockade by 8-SPT and BWA1433 (100 microM). 3. Remova...Continue Reading

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Citations

Apr 30, 2008·Purinergic Signalling·Manuela MoratoAntónio Albino-Teixeira
Dec 1, 2001·Pharmacology & Therapeutics·R Tabrizchi, S Bedi
Jul 17, 2001·British Journal of Pharmacology·S M HouraniD J Prentice
Aug 7, 2001·British Journal of Pharmacology·A Flood, J P Headrick
Jan 5, 2013·Journal of Cardiovascular Pharmacology·Bunyen TengS Jamal Mustafa
Jan 13, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Kim A Dora
Dec 3, 1999·The Journal of Physiology·A M Brunsden, D Grundy
Jul 19, 2011·Journal of Molecular and Cellular Cardiology·Petra KleinbongardGerd Heusch
Apr 19, 2005·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Naoshige HaradaYasuhiro Yamamoto
Jan 30, 2007·Journal of Molecular and Cellular Cardiology·Kevin J AshtonJohn P Headrick
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Jan 14, 2004·The Journal of Pharmacology and Experimental Therapeutics·S AkermanP J Goadsby
Oct 17, 2008·The Journal of Pharmacology and Experimental Therapeutics·Grzegorz GodlewskiGeorge Kunos
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Martin SteinmetzEberhard Schlatter
Dec 25, 2002·Journal of Cardiovascular Pharmacology·Andrea K HinschenJohn P Headrick
May 2, 2000·The Journal of Biological Chemistry·M MaccarroneA Finazzi-Agrò
Oct 8, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G H CristC H Lang
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A K HinschenJ P Headrick
Jun 11, 1999·The American Journal of Physiology·R D LasleyR M Mentzer
Jun 6, 2003·Pharmacology & Toxicology·Leposava Grbović, Miroslav Radenković

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