Activation of Type I and Type III Interferons in Chronic Hepatitis C.

Journal of Innate Immunity
Sabine Mihm

Abstract

Infection with hepatitis C virus (HCV) results in chronic and progressive liver disease. Persistency rates add up to 85%. Despite recognition of the virus by the human host in peripheral blood and in the liver, immune response appears to be ineffective in clearing infection. The ability to spontaneously eradicate the virus as well as the outcome of infection upon therapy with human recombinant interferon-α (IFN-α) was found to correlate most closely with genetic variations within the region encoding the IFN-λ genes, as revealed by genome-wide association studies on main ethnic populations in 2009. This review summarizes the induction of type I and type III IFN genes and their effectors, the IFN-stimulated genes. It focusses on the in vivo situation in chronic HCV infection in man both in the peripheral blood compartment and in the liver. It also addresses the impact of genetic polymorphisms in the region of type III IFN genes on their activation. Finally, it discusses how antiviral drugs (i.e. IFN-α, ribavirin and the direct-acting antivirals) may complementarily control the activation of endogenous IFNs and succeed in combatting infections.

Citations

Sep 8, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Jing WuLingxiang Mao
Nov 27, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M SidorkiewiczA Piekarska
Mar 16, 2017·Frontiers in Immunology·Mohammedyaseen Syedbasha, Adrian Egli
Jun 16, 2019·Nature Reviews. Immunology·Liang YePeter Staeheli
Nov 12, 2015·World Journal of Gastroenterology : WJG·María Martínez-EsparzaPilar García-Peñarrubia
Nov 3, 2020·World Journal of Gastroenterology : WJG·Simmone D'souzaTrushar R Patel
Aug 8, 2021·International Journal of Molecular Sciences·Henriette Huschka, Sabine Mihm

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