The activity of ventral tegmental area (VTA) dopamine (DA) neurons promotes behavioral responses to rewards and environmental stimuli that predict them. VTA GABA inputs synapse directly onto DA neurons and may regulate DA neuronal activity to alter reward-related behaviors; however, the functional consequences of selective activation of VTA GABA neurons remains unknown. Here, we show that in vivo optogenetic activation of VTA GABA neurons disrupts reward consummatory behavior but not conditioned anticipatory behavior in response to reward-predictive cues. In addition, direct activation of VTA GABA projections to the nucleus accumbens (NAc) resulted in detectable GABA release but did not alter reward consumption. Furthermore, optogenetic stimulation of VTA GABA neurons directly suppressed the activity and excitability of neighboring DA neurons as well as the release of DA in the NAc, suggesting that the dynamic interplay between VTA DA and GABA neurons can control the initiation and termination of reward-related behaviors.
Iontophoretically administered drugs acting at the N-methyl-D-aspartate receptor modulate burst firing in A9 dopamine neurons in the rat
Characterization of the impaired feeding behavior in rats given haloperidol or dopamine-depleting brain lesions
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo
Different effects of nucleus accumbens and ventrolateral striatal dopamine depletions on instrumental response selection in the rat
Heterogeneity of ventral tegmental area neurons: single-unit recording and iontophoresis in awake, unrestrained rats
GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo
D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
Nucleus accumbens dopamine depletions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement
Increases in food intake or food-seeking behavior induced by GABAergic, opioid, or dopaminergic stimulation of the nucleus accumbens: is it hunger?
Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning
Extinction of cocaine self-administration reveals functionally and temporally distinct dopaminergic signals in the nucleus accumbens
Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward-learning network
The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat.
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses.
Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior.
Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area
Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety.
Duration of inhibition of ventral tegmental area dopamine neurons encodes a level of conditioned fear.
Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits
Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system
Amygdala and bed nucleus of the stria terminalis circuitry: Implications for addiction-related behaviors
Carbon nanotube yarn electrodes for enhanced detection of neurotransmitter dynamics in live brain tissue
Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning
Integrating optogenetic and pharmacological approaches to study neural circuit function: current applications and future directions
Low dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in mice
Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking
Aversive stimuli differentially modulate real-time dopamine transmission dynamics within the nucleus accumbens core and shell
Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons
Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking
Dorsal and ventral streams: the distinct role of striatal subregions in the acquisition and performance of goal-directed actions
Aversive behavior induced by optogenetic inactivation of ventral tegmental area dopamine neurons is mediated by dopamine D2 receptors in the nucleus accumbens
Organization of afferents to the striatopallidal systems in the fire-bellied toad Bombina orientalis
Poststress block of kappa opioid receptors rescues long-term potentiation of inhibitory synapses and prevents reinstatement of cocaine seeking
Ventromedial prefrontal cortex pyramidal cells have a temporal dynamic role in recall and extinction of cocaine-associated memory
ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli
Optogenetic stimulation in a computational model of the basal ganglia biases action selection and reward prediction error
Pharmacological Manipulation of the Rostromedial Tegmental Nucleus Changes Voluntary and Operant Ethanol Self-Administration in Rats
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