Active and passive immunization against angiotensin II in the rat and rabbit. Evidence for a normal regulation of the renin-angiotensin system.

Circulation Research
P OsterE Hackenthal

Abstract

Active or passive immunization has been used repeatedly as a tool in studies on the role of the renin-angiotensin system in the control of blood pressure and kidney function. The results are not consistent among each other, and they are also at variance with other studies using different approaches. To evaluate the possible causes of these discrepancies, the biological characteristics of angiotensin antibodies were studied in rats. Following the intravenous injection of angiotensin II antibodies (purified by affinity chromatography), the plasma concentration of the antibodies declined in a two-exponential curve with half times of 11 hours and 7 days, which probably reflect distribution in the extracellular space and elimination, respectively. Plasma angiotensin II levels rose from preinjection levels of 100 pg/ml to 12,000 pg/ml within 10 minutes and then declined concomitantly with the decline in antibody concentration. We calculated that only a samll fraction of the circulating antibody was occupied by angiotensin II. Plasma renin concentrations were initially elevated both in controls and in antibody-injected rats, but they returned to the control level after 30 minutes and remained at that level throughout the rest of the e...Continue Reading

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Citations

Sep 1, 1985·Pflügers Archiv : European journal of physiology·H R KirchheimP Persson
Nov 1, 1987·Pflügers Archiv : European journal of physiology·H R KirchheimP Persson
Nov 1, 1987·Pflügers Archiv : European journal of physiology·H EhmkeH Kirchheim
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Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·H KirchheimP Persson
Aug 28, 1979·Biochimica Et Biophysica Acta·U Hilgenfeldt, E Hackenthal

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