Active and selective transcytosis of cell-free human immunodeficiency virus through a tight polarized monolayer of human endometrial cells

Journal of Virology
H HociniL Bélec

Abstract

We report that both primary and laboratory-adapted infectious human immunodeficiency virus type 1 (HIV-1) isolates in a cell-free form are capable of transcytosis through a tight and polarized monolayer of human endometrial cells. Trancytosis of cell-free HIV occurs in a strain-selective fashion and appears to be dependent on interactions between HIV envelope glycoproteins and lectins on the apical membrane of the epithelial cells. These findings provide new insights into the initial events occurring during heterosexual transmission of the virus.

References

Jan 1, 1992·Virology·D M Phillips, A S Bourinbaiar
Apr 10, 1997·The New England Journal of Medicine·R A RoyceM S Cohen
Jan 7, 1998·Journal of Virology·E L DelwartM K Singh
Jul 11, 1998·Virology·J FantiniN Yahi
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NijhuisJ Albert
Apr 4, 2000·Journal of Clinical Microbiology·R N ShepardS A Fiscus

❮ Previous
Next ❯

Citations

Sep 29, 2011·Archives of Virology·Bertran AuvertLaurent Bélec
Oct 23, 2004·The Journal of Infectious Diseases·Christine M RousseauJulie Overbaugh
Jul 16, 2010·American Journal of Physiology. Renal Physiology·J MikulakP C Singhal
Jan 11, 2013·Clinical & Developmental Immunology·Johanne PoudrierMichel Roger
Nov 22, 2014·The Journal of Infectious Diseases·Manish Sagar
Feb 26, 2013·Journal of Reproductive Immunology·Marta Rodriguez-GarciaCharles R Wira
Mar 23, 2005·Virology·Clarisse LorinFrédéric Tangy
Mar 9, 2005·Immunology Letters·Zoltán BánkiManfred P Dierich
Dec 22, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Giovanni Di Pasquale, John A Chiorini
May 4, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert W Coombs
Dec 17, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jun ZhengShen Pang
Mar 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruizhong ShenPhillip D Smith
Jul 3, 2020·Human Vaccines & Immunotherapeutics·Mariangela Cavarelli, Roger Le Grand
Aug 30, 2018·Disease Models & Mechanisms·Jocelyn M WesselsCharu Kaushic
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Héla SaidiLaurent Belec

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.