Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells

Journal of Virology
Anvita KumarLena Al-Harthi

Abstract

The Wnt/beta-catenin pathway is involved in cell functions governing development and disease. In modeling postentry restriction of human immunodeficiency virus (HIV) replication in astrocytes, we reported that part of this natural resistance to productive replication of HIV in astrocytes involved expression of proteins of the Wnt/beta-catenin signaling pathway. We determined here whether induction of beta-catenin signaling in peripheral blood mononuclear cells (PBMCs) can modulate HIV replication. Given that lithium is an inducer of beta-catenin signaling, we used it as a tool to determine the impact of beta-catenin signaling on HIV replication in PBMCs. We demonstrated that lithium inhibited the replication of T-tropic and primary isolates of HIV by >90% and did so in noncytotoxic/noncytostatic concentrations and in a beta-catenin-dependent manner. Specifically, inhibiting beta-catenin signaling by transfection of dominant-negative mutant constructs to either T-cell factor 4, the downstream effector of Wnt signaling, or beta-catenin, the central mediator of this pathway, abrogated the ability of lithium to inhibit HIV replication. Moreover, when Wnt/beta-catenin signaling was inhibited, the level of HIV replication was enhance...Continue Reading

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Citations

Mar 9, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Lisa J Henderson, Lena Al-Harthi
Oct 16, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Lena Al-Harthi
Jan 10, 2013·Pharmacological Reviews·Chi-Tso ChiuDe-Maw Chuang
Dec 14, 2011·Journal of Virology·Srinivas D NarasipuraLena Al-Harthi
Jun 28, 2013·Retrovirology·Carine Van LintAlessandro Marcello
Mar 26, 2010·AIDS Research and Therapy·Irene GuendelFatah Kashanchi
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Apr 25, 2014·Viruses·Amit KumarGeorges Herbein
Nov 15, 2013·Journal of Virology·Irene GuendelFatah Kashanchi
Jun 9, 2016·Reviews in Medical Virology·Wendy J van ZuylenCaroline E Ford
Nov 26, 2014·Viruses·Elisa De Crignis, Tokameh Mahmoudi
Feb 9, 2018·Viruses·Vanessa Sue WaclechePetronela Ancuta
Jan 13, 2018·Microbiology and Molecular Biology Reviews : MMBR·Jean-François GélinasStephen C Hyde
Apr 9, 2014·Infection and Immunity·Bruno Bezerra LimaGerly Anne de Castro Brito
Jul 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason M SchenkelLena Al-Harthi
Jun 19, 2013·Immunological Reviews·Deanna A KulpaRafick-Pierre Sékaly
May 13, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei LiLena Al-Harthi
Nov 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T UelandP Aukrust
Oct 1, 2018·Journal of Translational Medicine·Liang DuanWeixian Chen
Nov 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen H RichardsLena Al-Harthi
Sep 29, 2020·Frontiers in Microbiology·Conceição S MartinsGerly A C Brito
Dec 24, 2019·Frontiers in Microbiology·Zita Kruize, Neeltje A Kootstra
Feb 17, 2018·ELife·Fabio ZaniniStephen R Quake
Sep 6, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennillee WallaceLena Al-Harthi
Feb 10, 2021·Viruses·Antonio Victor Campos CoelhoLucas André Cavalcanti Brandão

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