Active collagen synthesis in infantile hypertrophic pyloric stenosis

Pediatric Surgery International
E MiyazakiP Puri

Abstract

M-57 antibody, which is capable of distinguishing newly-synthesized type I procollagen from fully-processed, mature collagen, was used to examine the expression of collagen synthesis in hypertrophic pyloric muscle from patients with infantile hypertrophic pyloric stenosis (IHPS). Seven specimens from IHPS patients were removed at the time of operation; age-matched normal pyloric tissue of 5 post-mortem cases was obtained as controls. Immunohistochemistry was performed using antibody of the amino-terminal end of the procollagen type I propeptide (M-57). Newly-synthesized procollagen (M-57) was strongly detected in both the connective tissue septa between circular muscle bundles, and among the circular-muscle fibers in patients with IHPS. No M-57 staining was observed among the circular-muscle fibers in controls. Our findings show that the hypertrophic circular muscle in IHPS is actively synthesizing collagen, and this may be responsible for the characteristic "firm" nature of the pyloric tumor.

Citations

Sep 18, 2009·Pediatric Surgery International·Christina Panteli
Jun 10, 2004·Journal of Pediatric Gastroenterology and Nutrition·Stefano ParriniClaudio De Felice
Dec 14, 2002·Anatomia, histologia, embryologia·R M AbelL Spitz
Oct 17, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Manfred Hauben, Guy W Amsden
Jul 11, 2012·Nature Reviews. Gastroenterology & Hepatology·Babette PeetersRaoul C M Hennekam
Jun 29, 2000·Journal of Pediatric Surgery·N GuarinoP Puri

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