PMID: 8601223Apr 1, 1996Paper

Active HHV-6 infection in the lymph nodes of HIV-infected patients: in vitro evidence that HHV-6 can break HIV latency

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
K K Knox, D R Carrigan

Abstract

Studies published previously by this laboratory have demonstrated that patients with AIDS have widely disseminated, active infections with HHV-6 at the time of their death. However, it remains unclear when in the course of the human immunodeficiency virus (HIV) infection the active HHV-6 infection first appears. To address this question, lymph node biopsies from 10 HIV-infected patients were analyzed for active human herpesvirus 6 (HHV-6) infections by immunohistochemical staining. Eight of the biopsies carried the histologic diagnosis of follicular hyperplasia; the other two were characterized as having follicular involution with histiocytosis and reactive lymphadenitis. In total, 10 of 10 (100%) of the lymph nodes studied contained cells productively infected with HHV-6; in contrast, three lymph nodes with follicular hyperplasia and four normal lymph nodes from patients not infected with HIV were negative for HHV-6 infection. Of special note, the absolute CD4+ lymphocyte counts of 75% (6/8) of the HIV-infected individuals included in these studies were > 200/mm3 at the time of their lymph node biopsy. The A variant of HHV-6 was found to be the predominant form of the virus present in the lymph node biopsies from all of these ...Continue Reading

References

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Citations

Mar 30, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J BaillargeonC T Leach
Mar 11, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tiansheng Chen, S David Hudnall
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Paolo LussoRobert C Gallo
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K K KnoxD R Carrigan
Apr 19, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J OngrádiA Horváth
Jul 31, 2006·Journal of Applied Social Psychology·Denise DixonMichael H Antoni
Jun 28, 2003·Journal of Virology·Kazushi NakanoKoichi Yamanishi
Feb 6, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Paolo Lusso
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LeUNKNOWN AST Infectious Diseases Community of Practice
Feb 13, 2003·British Journal of Haematology·Duncan A Clark, Paul D Griffiths
May 27, 2006·Virology·Martyn K WhiteKamel Khalili
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N Singh
Jan 28, 2004·Revista Do Instituto De Medicina Tropical De São Paulo·Ronaldo B FreitasAlexandre C Linhares
Sep 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·D R CarriganK K Knox
May 22, 2001·AIDS Patient Care and STDs·M T Caserta, C B Hall
Jun 11, 1999·Journal of Virology·P ZouK Yamanishi
Jul 1, 1997·Clinical Microbiology Reviews·D K BraunP E Pellett
Nov 4, 2000·Journal of Clinical Microbiology·G LocatelliM S Malnati

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