Active immunization against gonadotrophin-releasing hormone in Chinese male pigs

Reproduction in Domestic Animals = Zuchthygiene
X Y ZengX Zhang

Abstract

We have investigated, under the normal conditions of local Chinese pig farming, castration of young male pigs by vaccination with a newly developed vaccine against gonadotrophin releasing hormone (GnRH). Because of the very early onset of puberty, long fattening period and relatively harsh circumstances in Chinese pig production, an investigation of the endocrine response of Chinese breeds to this type of vaccination was of particular interest. Fifteen crossbred boars (Yorkshire x Yanan) from three different litters were randomly assigned to three groups of five animals each. The first group was immunized at 13 weeks of age with a GnRH tandem dimer OVA-conjugate in Specol and received a booster immunization 8 weeks later. The second group was injected with Specol alone and served as untreated controls. The remaining group was surgically castrated at the time of weaning (at 6 weeks of age). Pigs were fed ad libitum from weaning onwards. All animals were slaughtered at 31 weeks of age. Immunized boars had undetectable or low serum testosterone (0.09 +/- 0.12 ng/ml), low fat androstenone (0.05 +/- 0.01 microg/g) levels and very low testes weights (19.1 +/- 4.3 g). Intact controls had much higher serum levels of testosterone (9.76 ...Continue Reading

References

Sep 1, 1988·Journal of Reproduction and Fertility·C A AwoniyiR E Falvo
May 1, 1971·Journal of Animal Science·R A Field
Jun 18, 1998·Annals of the New York Academy of Sciences·R GlaserJ F Sheridan
Apr 1, 1990·Theriogenology·T MiyanoS Kanda
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·J A Long

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Citations

Dec 12, 2012·Animal : an International Journal of Animal Bioscience·N BatorekJ Van Milgen
Feb 28, 2003·American Journal of Reproductive Immunology : AJRI·Valerie A FerroWilliam H Stimson
Jun 20, 2019·Animals : an Open Access Journal From MDPI·Cristina BergaminAlberto Prandi

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