Abstract
Active immunization of four adult rhesus monkeys with highly purified ovine follicle-stimulating hormone (FSH) over 4 1/2 years resulted in the production of specific FSH antibodies. While luteinizing hormone and testosterone secretion were not affected, sperm counts were in most instances reduced to or below the lower normal range. On a few occasions, azoospermia or high sperm counts were observed. Although the antibodies produced neutralized the biologic activity of FSH throughout, spermatogenesis gradually returned, as evidenced by testicular histologic characteristics. However, the diameter of the seminiferous tubules remained decreased, and the germinal epithelium was depleted. No adverse side effects could be demonstrated in the immunized animals, e.g., immune complexes in either serum or tissues and resultant tissue damage. These results show that although active immunization with FSH may not result in an effective method of male fertility control, long-term immunization against a circulating hormone may not result in deleterious side effects.
Citations
Jul 1, 1988·Clinical Endocrinology·R I McLachlanH G Burger
Feb 12, 2017·Andrology·M ZitzmannE Nieschlag
Jul 1, 1995·American Journal of Reproductive Immunology : AJRI·R SureshN R Moudgal
Jan 1, 1993·American Journal of Reproductive Immunology : AJRI·G M ButtersteinJ A Dias
Dec 31, 1997·Endocrine Reviews·M SimoniE Nieschlag
Dec 12, 2001·Endocrine Reviews·T M Plant, G R Marshall
Aug 1, 1991·Cell and Tissue Research·S SchlattE Nieschlag
Sep 1, 1999·Clinical Endocrinology·E NieschlagG F Weinbauer
Nov 23, 2013·Human Vaccines & Immunotherapeutics·Satish Kumar GuptaVidisha Minhas
Oct 1, 1988·Clinical Endocrinology·F C Wu
Jan 1, 1991·Annals of the New York Academy of Sciences·G F Weinbauer, E Nieschlag
Mar 14, 2000·Archives of Medical Research·J LevalletI T Huhtaniemi
Apr 1, 1995·Trends in Endocrinology and Metabolism : TEM·R I McLachlanD M de Kretser
Jun 20, 2002·Protein Expression and Purification·Leslie LobelJoyce W Lustbader
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·D M de KretserN G Wreford
Dec 24, 2005·Contraception·Jennifer P BarfieldTrevor G Cooper