Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome

Translational Research : the Journal of Laboratory and Clinical Medicine
Viktor H KoelzerInti Zlobec

Abstract

Tumor budding (single tumor cells or small tumor cell clusters) at the invasion front of colorectal cancer (CRC) is an adverse prognostic indicator linked to epithelial-mesenchymal transition. This study characterized the immunogenicity of tumor buds by analyzing the expression of the major histocompatibility complex (MHC) class I in the invasive tumor cell compartment. We hypothesized that maintenance of a functional MHC-I antigen presentation pathway, activation of CD8+ T-cells, and release of antitumoral effector molecules such as cytotoxic granule-associated RNA binding protein (TIA1) in the tumor microenvironment can counter tumor budding and favor prolonged patient outcome. Therefore, a well-characterized multipunch tissue microarray of 220 CRCs was profiled for MHC-I, CD8, and TIA1 by immunohistochemistry. Topographic expression analysis of MHC-I was performed using whole tissue sections (n = 100). Kirsten rat sarcoma viral oncogene homolog (KRAS) and B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations, mismatch repair (MMR) protein expression, and CpG-island methylator phenotype (CIMP) were investigated. Our results demonstrated that membranous MHC-I expression is frequently down-regulated in the process of i...Continue Reading

References

Sep 15, 1990·International Journal of Cancer. Journal International Du Cancer·M R OlivaF Garrido
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Derek AtkinsBarbara Seliger
Jul 9, 2005·International Journal of Cancer. Journal International Du Cancer·Nicholas F S WatsonLindy G Durrant
Feb 18, 2010·International Journal of Cancer. Journal International Du Cancer·Inti ZlobecAlessandro Lugli
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernhard MlecnikJérôme Galon
Feb 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Niels HalamaChristine S Falk
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jan 20, 2012·Cancer Immunology, Immunotherapy : CII·Emilia AnderssonGiuseppe V Masucci
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Sep 29, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eva KaramitopoulouAlessandro Lugli
Oct 15, 2013·The Journal of Pathology·Jérôme GalonFranck Pagès

❮ Previous
Next ❯

Citations

Jan 15, 2016·British Journal of Cancer·Nicole MaxCord Langner
Oct 20, 2015·Human Pathology·Viktor H KoelzerAlessandro Lugli
Aug 28, 2015·Journal of Translational Medicine·Lena SokolAlessandro Lugli
Jun 17, 2015·Virchows Archiv : an International Journal of Pathology·Nicolas A GiraldoWolf H Fridman
Apr 14, 2017·Journal of Pathology and Translational Medicine·Hyeon Jeong OhGyeong Hoon Kang
Sep 10, 2020·Nature Reviews. Clinical Oncology·Alessandro LugliIris D Nagtegaal
Sep 9, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernhard MlecnikJérôme Galon
Nov 25, 2018·Virchows Archiv : an International Journal of Pathology·Viktor H KoelzerKirsten D Mertz
Apr 19, 2020·International Journal of Colorectal Disease·Jinyuan LiKunmei Gong
Dec 19, 2019·Cancers·Patrícia Dias CarvalhoSérgia Velho
Sep 4, 2019·Immunotherapy·Joanne Ec SohRahman Jamal
Jul 21, 2020·British Journal of Cancer·Stephanie G CraigManuel Salto-Tellez
May 12, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shintaro YokoyamaKoichi Ohshima
Sep 30, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James H ParkJoanne Edwards
Apr 18, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin WartenbergEva Karamitopoulou
Dec 12, 2017·Emerging Topics in Life Sciences·Maulik Patel
Dec 24, 2020·International Journal of Molecular Sciences·Luigi LaghiAlberto Malesci
Mar 27, 2021·Frontiers in Immunology·Karthik DhatchinamoorthyKenneth L Rock
Jan 15, 2021·The American Journal of Surgical Pathology·Sun-Young JunJoon-Yong Chung
Jun 3, 2021·Genes & Development·Jiexi LiRonald A DePinho

❮ Previous
Next ❯

Related Concepts