Active interleukin-1 receptor required for maximal progression of acute pancreatitis

Annals of Surgery
J G NormanM Glaccum

Abstract

The authors' aim was to determine the requirement for an active interleukin (IL)-1 receptor during the development and progression of acute pancreatitis. Interleukin-1 is a pro- inflammatory cytokine that has been shown to be produced during acute pancreatitis. Earlier animal studies of moderate and severe pancreatitis have shown that blockade of this powerful mediator is associated with attenuated pancreatic destruction and dramatic increases in survival. The exact role played by IL-1 and the requirement for activation of its receptor in the initiation and progression of pancreatitis is unknown. Conventional and IL-1 receptor "knockout" animals were used in parallel experiments of acute pancreatitis induced by intraperitoneal injection of cerulean (50 microg/kg every 1 hour X 4). The conventional mouse strain had the IL-1 receptor blocked prophylactically by means of a recombinant IL-1 receptor antagonist (10 mg/kg injected intraperitoneally every 2 hours). The second mouse strain was genetically engineered by means of gene targeting in murine embryonic stem cells to be devoid of type 1 IL-1 receptor (IL-1 receptor knockout). Animals were killed at 0, 0.5, 1, 2, 4, and 8 hours, with the severity of pancreatitis determined by s...Continue Reading

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Citations

Feb 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J NormanD Livingston
Aug 5, 2010·Pancreas·Lourenilson José SouzaMarcel Cerqueira Cesar Machado
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Rafaz HoqueWajahat Z Mehal
May 21, 2003·Critical Reviews in Clinical Laboratory Sciences·Carlos A RettallySteven Schenker
Jan 3, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·I-Mo FangMuh-Shy Chen
Mar 21, 2007·Digestive Diseases and Sciences·Xi-Ping ZhangYi-Feng Zhou
Mar 15, 2012·Pancreas·Rafaz HoqueWajahat Z Mehal
Nov 12, 2014·World Journal of Gastroenterology : WJG·Karolina Akinosoglou, Charalambos Gogos
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·J L FrossardC M Pastor
Jun 11, 2014·Scandinavian Journal of Gastroenterology·Mustafa KaplanOsman Metin Ipcioglu
Feb 24, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rafaz Hoque, Wajahat Z Mehal
Dec 10, 2009·Digestive Diseases and Sciences·Zhong Wei ZhangLiang Wu
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