Active Natural Product Scaffolds against Trypanosomatid Parasites: A Review

Journal of Natural Products
Peter E Cockram, Terry K Smith

Abstract

Neglected tropical diseases caused by trypanosomatid parasites are a continuing and escalating problem, which devastate the less economically developed cultures in countries in which they are endemic by impairing both human and animal health. Current drugs for these diseases are regarded as out-of-date and expensive, with unacceptable side-effects and mounting parasite resistance, meaning there is an urgent need for new therapeutics. Natural products have long been a source of potent, structurally diverse bioactive molecules. Herein are reviewed natural products with reported trypanocidal activity, which have been clustered based on core structural similarities, to aid the future discovery of new trypanocidal core motifs with potential routes to synthetically accessible natural product cores suggested.

References

Dec 24, 1996·Biochemical Pharmacology·M P Molina PortelaA O Stoppani
Feb 7, 2002·Expert Opinion on Investigational Drugs·Claudius D'Silva, Sylvie Daunes
Mar 2, 2002·The Journal of Organic Chemistry·Masahiko IsakaYodhathai Thebtaranonth
Jul 26, 2002·Journal of Medicinal Chemistry·Tim H M JonckersLuc Pieters
Jul 27, 2002·BMJ : British Medical Journal·Gavin Yamey, Els Torreele
Dec 11, 2002·Trends in Parasitology·John P Kabayo
Jan 25, 2003·Journal of Natural Products·Nahoko UchiyamaOzodbek A Ashurmetov
Jun 26, 2004·Journal of Natural Products·Djibril FallReynald Hocquemiller
Aug 5, 2004·Journal of Agricultural and Food Chemistry·Valentine RagoussisNikitas Ragoussis
Jan 19, 2006·Clinical Microbiology Reviews·Simon L CroftAlan H Fairlamb
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andreas SchirmerDaniel V Santi
Mar 3, 2007·Journal of Natural Products·Roger G LiningtonWilliam H Gerwick
May 10, 2007·Journal of Combinatorial Chemistry·Nianhuan YaoKit S Lam
Apr 30, 2008·Antimicrobial Agents and Chemotherapy·Valeria P SülsenVirginia S Martino
Aug 8, 2008·Journal of Natural Products·Alexander PontiusGabriele M König
Sep 30, 2008·PLoS Neglected Tropical Diseases·Maha-Hamadien AbdullaJames H McKerrow
Jan 13, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anders VikLise-Lotte Gundersen
May 16, 2009·Plant Foods for Human Nutrition·Liu PengfeiWang Jianguo
Jun 9, 2009·Free Radical Biology & Medicine·Rubem F S Menna-BarretoSolange L de Castro
Jun 11, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thomas J SchmidtReto Brun
Jul 11, 2009·The Journal of Organic Chemistry·Tony V RobinsonEdward R T Tiekink
Jan 5, 2010·Journal of Liquid Chromatography & Related Technologies·Xiaoying CaoYoichiro Ito
Mar 20, 2010·Journal of Natural Products·Yunjiang FengRonald J Quinn
Apr 15, 2010·Marine Drugs·Sheila Marie Pimentel-ElardoUte Hentschel
May 5, 2010·Antimicrobial Agents and Chemotherapy·Antoaneta Y SokolovaAlan H Fairlamb
Jun 16, 2010·Molecular Microbiology·Natasha SienkiewiczAlan H Fairlamb
Aug 18, 2010·Marine Drugs·Fernando ScalaDeniz Tasdemir
Dec 3, 2010·Bioorganic & Medicinal Chemistry·Caterina FattorussoOrazio Taglialatela-Scafati
Dec 23, 2010·Organic Letters·Gordon J FlorenceTerry K Smith
Feb 15, 2011·Bioorganic & Medicinal Chemistry·Julien DefauxDiego Muñoz-Torrero
Apr 5, 2011·Bioorganic & Medicinal Chemistry·Tran Hong QuangYoung Ho Kim
Apr 15, 2011·Chemistry : a European Journal·Xiao-Yu SunHenry N C Wong
Apr 19, 2011·International Journal of Antimicrobial Agents·Valeria P SülsenVirginia S Martino
Jun 28, 2011·Bioorganic & Medicinal Chemistry·Rohan A DavisRonald J Quinn
Aug 19, 2011·Journal of Natural Products·Susanna T S ChanBrent R Copp
Sep 6, 2011·European Journal of Medicinal Chemistry·Bhuwan B Mishra, Vinod K Tiwari

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Citations

Nov 30, 2019·International Journal of Molecular Sciences·Susiany P LopesDamião P de Sousa
Oct 6, 2020·Organic & Biomolecular Chemistry·Matthew J AnketellIan Paterson
Dec 19, 2019·RSC Medicinal Chemistry·Markos-Orestis GeorgiadisJohn M Kelly
Jan 23, 2021·RSC Medicinal Chemistry·Orlagh AndersonPaul W Denny
Jun 16, 2021·Bioorganic & Medicinal Chemistry·Koichi NaritaYuichi Yoshimura
Sep 9, 2021·Clinical Microbiology Reviews·Oyelola AdegboyeClaire Loiseau

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