PMID: 15372116Sep 17, 2004Paper

Active peptic ulcer disease in patients with hepatitis C virus-related cirrhosis: the role of Helicobacter pylori infection and portal hypertensive gastropathy

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
Maria Pina DoreGiuseppe Realdi

Abstract

The relationship between Helicobacter pylori infection and peptic ulcer disease in cirrhosis remains controversial. The purpose of the present study was to investigate the role of H pylori infection and portal hypertension gastropathy in the prevalence of active peptic ulcer among dyspeptic patients with compensated hepatitis C virus (HCV)-related cirrhosis. Patients undergoing upper endoscopy with compensated HCV-related cirrhosis were enrolled. Child-Pugh's score was determined at the entry. Variceal size was measured endoscopically and the severity of portal hypertensive gastropathy was graded. H pylori infection status was determined by urea breath testing and/or histology. A total of 178 patients positive for HCV (A and B Child-Pugh's score) were prospectively included. The prevalence of H pylori infection was 43%. An active peptic ulcer was found in 14 patients (8%) and was significantly more common among those with H pylori infection (16% versus 2% in H pylori uninfected patients, odds ratio: 8.0). No association was observed between H pylori infection and variceal size, or hypertensive gastropathy. Patients with compensated cirrhosis and H pylori infection showed higher risk of developing a peptic ulcer. Clinical releva...Continue Reading

Citations

Apr 1, 2006·The American Journal of Gastroenterology·Robert J FontanaUNKNOWN HALT-C Trial Group
Mar 28, 2008·The Korean Journal of Internal Medicine·Dong Joon KimChoong Kee Park
May 22, 2008·World Journal of Gastroenterology : WJG·Francesca LodatoGiuseppe Mazzella
Jul 14, 2020·Postgraduate Medicine·Harshil ShahWilbert Aronow
Aug 27, 2009·Alimentary Pharmacology & Therapeutics·J P Gisbert, X Calvet
Mar 17, 2010·Arquivos De Gastroenterologia·Rozangela Maria de Almeida Fernandes WyszomirskaCláudio Torres Miranda
Dec 9, 2010·The American Journal of Gastroenterology·Robert J FontanaUNKNOWN HALT-C Trial Study Group

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