Abstract
Plasma phospholipid transfer protein (PLTP) is a multifaceted protein with diverse biological functions. It has been shown to exist in both active and inactive forms. To determine the nature of lipoproteins associated with active PLTP, plasma samples were adsorbed with anti-A-I, anti-A-II, or anti-E immunoadsorbent, and PLTP activity was measured in the resulting plasma devoid of apolipoprotein A-I (apoA-I), apoA-II, or apoE. Anti-A-I and anti-A-II immunoadsorbents removed 98 +/- 1% (n = 8) and 38 +/- 25% (n = 7) of plasma PLTP activity, respectively. In contrast, only 1 +/- 5% of plasma PLTP activity was removed by anti-E immunoadsorbent (n = 7). Dextran sulfate (DS) cellulose did not bind apoA-I, but it removed 83 +/- 5% (n = 4) of the PLTP activity in plasma. In size-exclusion chromatography, PLTP activity removed by anti-A-I or anti-A-II immunoadsorbent was associated primarily with particles of a size corresponding to HDL, whereas a substantial portion of the PLTP activity dissociated from DS cellulose was found in particles larger or smaller than HDL. These data show the following: 1) active plasma PLTP is associated primarily with apoA-I- but not apoE-containing lipoproteins; 2) active PLTP is present in HDL particles wi...Continue Reading
References
Oct 26, 1979·Biochimica Et Biophysica Acta·R W MahleyT L Innerarity
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Nov 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S YokoyamaA Yamamoto
Jan 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J J AlbersA Steinmetz
Sep 14, 1982·Biochimica Et Biophysica Acta·J DamenG Scherphof
Jan 15, 1995·The Biochemical Journal·G M KostnerH Dieplinger
Jan 1, 1993·International Journal of Clinical & Laboratory Research·M C Cheung
May 24, 1996·The Journal of Biological Chemistry·E HailmanS D Wright
Jun 11, 1996·Biochimica Et Biophysica Acta·A von EckardsteinG Assmann
Sep 27, 1996·Biochimica Et Biophysica Acta·M C CheungJ J Albers
Mar 14, 1997·The Journal of Biological Chemistry·H I Nishida, T Nishida
May 4, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C DesrumauxL Lagrost
Jul 9, 1999·Biochimica Et Biophysica Acta·G WolfbauerJ F Oram
Aug 14, 2001·The Journal of Biological Chemistry·C P LibeuK H Weisgraber
Feb 21, 2002·The Journal of Biological Chemistry·Minna KärkkäinenChristian Ehnholm
Jun 18, 2003·Journal of Lipid Research·Sarah SigginsChristian Ehnholm
Aug 2, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Takeshi KujiraokaNorman E Miller
Oct 16, 2003·The Journal of Biological Chemistry·John F OramJohn J Albers
Apr 23, 2005·Biochemical and Biophysical Research Communications·Minna T JänisChristian Ehnholm
Citations
Jul 30, 2010·Biochemistry·Marian C CheungJohn J Albers
Nov 11, 2006·Current Opinion in Lipidology·David Akopian, Jheem D Medh
May 15, 2007·Current Opinion in Lipidology·Geesje M Dallinga-ThieArie van Tol
Dec 13, 2012·American Journal of Physiology. Endocrinology and Metabolism·Norman E MillerM Nazeem Nanjee
Jul 25, 2009·Lipids in Health and Disease·Ryan J HendersonCarlos G Leon
Jun 11, 2010·Lipids in Health and Disease·Marius R RobciucMatti Jauhiainen
Aug 18, 2012·Nutrition & Metabolism·Xian-Cheng JiangMahmood M Hussain
Apr 22, 2009·Drug Development and Industrial Pharmacy·Ryan J HendersonKishor M Wasan
Jul 9, 2011·Biochimica Et Biophysica Acta·John J AlbersMarian C Cheung
Feb 10, 2011·Biochimica Et Biophysica Acta·Marian C CheungJohn J Albers
Jun 8, 2007·Atherosclerosis·Wilfried SchgoerBernhard Foeger
May 6, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T TzotzasL Lagrost
Sep 9, 2015·Journal of Lipids·Roy A Garvin
Mar 27, 2009·Biochimica Et Biophysica Acta·Simona VuleticJohn J Albers
May 27, 2015·Journal of Lipid Research·Daniel Seung KimGail P Jarvik
Oct 9, 2007·Journal of Lipid Research·Nongnuch SettasatianKerry-Anne Rye
Feb 14, 2018·Journal of Lipid Research·Xian-Cheng Jiang
Oct 14, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Ruijie LiuXian-Cheng Jiang
Apr 18, 2012·Circulation·Robert S RosensonLaurent Yvan-Charvet
Jan 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·David MassonLaurent Lagrost
Jan 27, 2021·Current Atherosclerosis Reports·Xian-Cheng Jiang, Yang Yu