Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins.

Journal of Lipid Research
Marian C Cheung, J J Albers

Abstract

Plasma phospholipid transfer protein (PLTP) is a multifaceted protein with diverse biological functions. It has been shown to exist in both active and inactive forms. To determine the nature of lipoproteins associated with active PLTP, plasma samples were adsorbed with anti-A-I, anti-A-II, or anti-E immunoadsorbent, and PLTP activity was measured in the resulting plasma devoid of apolipoprotein A-I (apoA-I), apoA-II, or apoE. Anti-A-I and anti-A-II immunoadsorbents removed 98 +/- 1% (n = 8) and 38 +/- 25% (n = 7) of plasma PLTP activity, respectively. In contrast, only 1 +/- 5% of plasma PLTP activity was removed by anti-E immunoadsorbent (n = 7). Dextran sulfate (DS) cellulose did not bind apoA-I, but it removed 83 +/- 5% (n = 4) of the PLTP activity in plasma. In size-exclusion chromatography, PLTP activity removed by anti-A-I or anti-A-II immunoadsorbent was associated primarily with particles of a size corresponding to HDL, whereas a substantial portion of the PLTP activity dissociated from DS cellulose was found in particles larger or smaller than HDL. These data show the following: 1) active plasma PLTP is associated primarily with apoA-I- but not apoE-containing lipoproteins; 2) active PLTP is present in HDL particles wi...Continue Reading

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Citations

Nov 11, 2006·Current Opinion in Lipidology·David Akopian, Jheem D Medh
Dec 13, 2012·American Journal of Physiology. Endocrinology and Metabolism·Norman E MillerM Nazeem Nanjee
Jul 25, 2009·Lipids in Health and Disease·Ryan J HendersonCarlos G Leon
Jun 11, 2010·Lipids in Health and Disease·Marius R RobciucMatti Jauhiainen
Aug 18, 2012·Nutrition & Metabolism·Xian-Cheng JiangMahmood M Hussain
Jul 9, 2011·Biochimica Et Biophysica Acta·John J AlbersMarian C Cheung
Jun 8, 2007·Atherosclerosis·Wilfried SchgoerBernhard Foeger
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Mar 27, 2009·Biochimica Et Biophysica Acta·Simona VuleticJohn J Albers
Oct 14, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Ruijie LiuXian-Cheng Jiang
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Jan 27, 2021·Current Atherosclerosis Reports·Xian-Cheng Jiang, Yang Yu

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