PMID: 8467353Mar 1, 1993Paper

Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers

British Journal of Pharmacology
N M GriffithsN L Simmons

Abstract

The bidirectional transepithelial fluxes of ciprofloxacin, an antibacterial fluoroquinolone, across the human intestinal epithelial Caco-2 cell-line show marked asymmetry. Basal-to-apical flux of ciprofloxacin (10 microM) exceeds apical-to-basal flux indicating net secretion. Net ciprofloxacin secretion is abolished by azide/2-deoxy-D-glucose treatment, displays saturation kinetics (Km = 0.89 +/- 0.23 mM, Vmax 44.3 +/- 4.9 nmol cm-2.h) and competition by other fluoroquinolones. A specific, active secretion in Caco-2 epithelia may explain the transintestinal elimination of ciprofloxacin observed in pharmacokinetic studies in man.

References

Dec 30, 1991·The American Journal of Medicine·F SorgelP Muth
Dec 16, 1991·Biochemical and Biophysical Research Communications·J HunterN L Simmons
Jan 1, 1990·Chemotherapy·R RohwedderH Scholl
Mar 1, 1990·Diagnostic Microbiology and Infectious Disease·R W RohwedderH Scholl
Jan 1, 1984·Drug Metabolism Reviews·Z H Israili, P G Dayton

❮ Previous
Next ❯

Citations

Mar 1, 1995·Medicinal Research Reviews·K M HillgrenR T Borchardt
Jun 6, 2000·Advanced Drug Delivery Reviews· T Borchardt RG M Pauletti
Aug 1, 1997·British Journal of Pharmacology·M E CavetN L Simmons
Aug 24, 1999·British Journal of Pharmacology·S DautreyR Farinotti
Mar 6, 2002·British Journal of Pharmacology·Simon Lowes, Nicholas L Simmons
Sep 21, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·I S HaslamN L Simmons
Sep 15, 2001·Antimicrobial Agents and Chemotherapy·H AbdelghaffarM T Labro
Jan 18, 2002·Antimicrobial Agents and Chemotherapy·Kazumasa NaruhashiAkira Tsuji
Dec 10, 1999·Journal of Clinical Pharmacology·D K Yu
Jan 18, 2008·Journal of Pharmaceutical Sciences·Ana I AlvarezGracia Merino
Nov 17, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Akira Tsuji
Mar 1, 2008·Journal of Veterinary Pharmacology and Therapeutics·A HartmannK Hartmann
May 17, 2011·Archives of Drug Information·Miki Susanto ParkLeslie Z Benet
Feb 15, 2013·Journal of Veterinary Pharmacology and Therapeutics·P Lees
Mar 13, 2014·Journal of Veterinary Pharmacology and Therapeutics·M BallentA Lifschitz
Jan 9, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C Fernandez-TeruelM Bermejo
Nov 15, 2011·The Veterinary Journal·Mariana BallentCarlos Lanusse
May 24, 2001·The Journal of Pharmacy and Pharmacology·K NaruhashiA Tsuji
Sep 1, 1999·The Journal of Pharmacy and Pharmacology·K KawazuA Ota
Nov 1, 1995·Clinical Pharmacology and Therapeutics·U JaehdeW Schunack
May 8, 2004·The Journal of Pharmacology and Experimental Therapeutics·Hiroyuki SasabeYuichi Sugiyama
Jan 26, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gracia MerinoJulio G Prieto
Oct 5, 2018·Frontiers in Microbiology·Kaitlyn M FergusonDerek M Foster
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·E Cormet-BoyakaD Tomé
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·S DautreyR Farinotti
Jan 30, 1999·Antimicrobial Agents and Chemotherapy·D VazifehM T Labro
Apr 19, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Irene Hernández-LozanoOliver Langer
Oct 23, 1997·Antimicrobial Agents and Chemotherapy·L RabbaaR Farinotti
Jan 7, 1998·Antimicrobial Agents and Chemotherapy·M E CavetN L Simmons
Nov 1, 1996·Antimicrobial Agents and Chemotherapy·S J van den HazelD J van Leeuwen
Sep 1, 1996·Antimicrobial Agents and Chemotherapy·L RabbaaR Farinotti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.