PMID: 6853254Apr 1, 1983Paper

Active specific immunotherapy using the immune reaction of a low-dose irradiated tumor tissue

International Journal of Radiation Oncology, Biology, Physics
Y OgawaS Kimura


Active specific immunotherapy using the immune reaction of a low-dose irradiated tumor tissue was studied on the transplanted MM46 tumor of female C3H/He mice after radiotherapy. MM46 tumor cells were inoculated into the right hind paws of mice. On the 5th day, irradiation with the dose of 3000 rad was performed. On the 11th day, tumor cells and mononuclear cells, which were separated from the low-dose irradiated tumor tissue (2000 rad on the fifth day), were injected into the left hind paws of the tumor-bearing mice. Effectiveness of this active specific immunotherapy against tumor was evaluated by the regression of tumor and survival rate of mice. Tumor was markedly regressed and survival rate was significantly increased by the active specific immunotherapy.


Feb 1, 1976·AJR. American Journal of Roentgenology·J M SlaterB H Lau
Jan 1, 1976·Oncology·H Wrba
Nov 1, 1969·Cancer·T J CunninghamJ Sullivan
May 15, 1974·International Journal of Cancer. Journal International Du Cancer·D Le FrançoisG Barski

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