PMID: 9001571Nov 1, 1996Paper

Active specific immunotherapy with hapten-modified autologous melanoma cell vaccine

Cancer Immunology, Immunotherapy : CII
T Sato

Abstract

We have developed a novel approach to cancer immunotherapy-an autologous whole-cell vaccine modified with the hapten dinitrophenyl (DNP). This approach elicits significant inflammatory responses in metastatic sites and some objective tumor responses. Post-surgical adjuvant immunotherapy with DNP-modified melanoma vaccine in a setting of micrometastatic disease produces significant survival prolongation in stage III melanoma patients. Histologically, the inflammatory responses of the tumor consist of infiltration by lymphocytes, the majority of which are CD8+, HLA-DR+ T cells. T cells from these lesions tend to have mRNA for interferon gamma. T cell receptor analysis suggests that the tumor-infiltrating T cells are clonally expanded. DNP-modified vaccine also induces T cells in the peripheral blood, which respond to DNP-modified autologous cells in a hapten-specific, MHC-restricted manner. Moreover, a T cell line generated from these lymphocytes responded to only a single HPLC fraction of MHC-associated, DNP-modified tumor peptides. Since inflammatory responses in metastases were not consistently associated with dramatic tumor regression, we considered the possibility of immunosuppression at the tumor site. We found that mRNA fo...Continue Reading

Citations

Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·S MocellinF M Marincola
Oct 20, 1998·International Journal of Immunopharmacology·K TakahashiY Monden
Aug 5, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S Ben-EfraimE H Relyveld
Jan 20, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I LalaniA R Ahmed
Oct 31, 2001·Journal of Immunotherapy·Simone MocellinFrancesco Maria Marincola
Apr 9, 2010·Melanoma Research·Senthamil R SelvanRobert O Dillman
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pierre L TriozziRobert M Conry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.