PMID: 16501710Feb 28, 2006Paper

Active surveillance for congenital rubella syndrome in Yangon, Myanmar

Bulletin of the World Health Organization
Kyaw-Zin ThantSusan E Robertson

Abstract

Rubella vaccine is not included in the immunization schedule in Myanmar. Although surveillance for outbreaks of measles and rubella is conducted nationwide, there is no routine surveillance for congenital rubella syndrome (CRS). Therefore, we organized a study to assess the burden of CRS. From 1 December 2000 to 31 December 2002 active surveillance for CRS was conducted among children aged 0-17 months at 13 hospitals and 2 private clinics in Yangon, the capital city. Children with suspected CRS had a standard examination and a blood sample was obtained. All serum samples were tested for rubella-specific IgM; selected samples were tested for rubella-specific IgG and for rubella RNA by reverse transcriptase-polymerase chain reaction (RT-PCR). A total of 81 children aged 0-17 months were suspected of having CRS. Of these, 18 children had laboratory-confirmed CRS (7 were IgM positive; 7 were RT-PCR positive; and 10 were IgG positive at > 6 months of age). One additional child who tested positive by RT-PCR and whose mother had had rubella during pregnancy but who had a normal clinical examination was classified as having congenital rubella infection. During 2001-02 no rubella outbreaks were detected in Yangon Division. In the 31 urb...Continue Reading

Citations

Jan 25, 2017·International Journal of Pediatrics·Anna Lena LopezRicardo Manalastas
Jun 4, 2019·Journal of Tropical Pediatrics·Rakesh Kumar PilaniaMeenu Singh
Nov 2, 2014·The Journal of Infectious Diseases·Terri B HydeUNKNOWN CRS Biomarker Study Group
Mar 24, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alexandre YazigiOlivier Picone
Jul 27, 2018·Human Vaccines & Immunotherapeutics·Seyed Mohsen ZahraeiManoochehr Karami
Oct 6, 2021·The Pediatric Infectious Disease Journal·Elisabeth Siti Herini Gunadi

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