Active surveillance of small-scale spatial cancer clusters: presentation of a new monitoring approach for the epidemiological Cancer Registry of Lower Saxony

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
J Kieschke, M Hoopmann

Abstract

Cancer registries often receive inquiries on possible cancer clusters. In 2010, the Cancer Registry of Lower Saxony reported on a spatial leukemia accumulation in the community of Asse. As a result, the Cancer Registry was engaged in developing an approach for a regional cancer monitoring program by the federal government. The modular approach involves a two-stage process. First, all regional monitoring areas are under surveillance, and in the second phase, noticeable areas only are observed further. A positive confirmation test is regarded as an initial concern and may lead to further investigations. The standardized incidence ratio (SIR) is used in the first stage. For confirmation, the Sequential Probability Ratio Test (SPRT) is applied in the second stage. All new observations are tested at a given time. The SPRT tests the null hypothesis (no increase) and an alternative hypothesis (increase) leading to three possible conclusions: warning, all-clear, or further surveillance necessary. A high false alarm rate due to clustering by chance is to be considered with multiple statistical testing. The number of false alarms depends on the number of tested areas, diagnoses, subgroup analyses, and time periods. Preliminary considerat...Continue Reading

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Citations

Apr 6, 2018·BMC Cancer·Tammo Konstantin ReindersVerena Jürgens
Oct 25, 2017·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Ron PritzkuleitAlexander Katalinic

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