Active-targeting and acid-sensitive pluronic prodrug micelles for efficiently overcoming MDR in breast cancer.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Cheng XuRupei Tang

Abstract

Multidrug resistance (MDR) seriously hinders therapeutic efficacy in clinical cancer treatment. Herein, we reported new polymeric prodrug micelles with tumor-targeting and acid-sensitivity properties based on two different pluronic copolymers (F127 and P123) for enhancing tumor MDR reversal and chemotherapy efficiency in breast cancer. Hybrid micelles were composed of phenylboric acid (PBA)-modified F127 (active-targeting group) and doxorubicin (DOX)-grafted P123 (prodrug groups), which were named as FBP-CAD. FBP-CAD exhibited good stability in a neutral environment and accelerated drug release under mildly acidic conditions by the cleavage of β-carboxylic amides bonds. In vitro studies demonstrated that FBP-CAD significantly increased cellular uptake and drug concentration in MCF-7/ADR cells through the homing ability of PBA and the anti-MDR effect of P123. In vivo testing further indicated that hybrid micelles facilitated drug accumulation at tumor sites as well as reduced side effects to normal organs. The synergistic effect of active-targeting and MDR-reversal leads to the highest tumor growth inhibition (TGI 78.2%). Thus, these multifunctional micelles provide a feasible approach in nanomedicine for resistant-cancer treatm...Continue Reading

References

Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Natalya RapoportJared L Nelson
Jun 7, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena V Batrakova, Alexander V Kabanov
Apr 7, 2009·Nano Letters·Steven D PerraultWarren C W Chan
May 19, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Fei YanLaiqiang Huang
May 26, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M Intakhab AlamM Akbar
Feb 16, 2012·Chemical Society Reviews·Mahmoud Elsabahy, Karen L Wooley
Aug 27, 2013·Advanced Drug Delivery Reviews·Niravkumar R PatelVladimir P Torchilin
Nov 22, 2014·ACS Applied Materials & Interfaces·Diankui SunXuesi Chen
Aug 19, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei MiaoLeaf Huang
Feb 1, 2017·Journal of Drug Targeting·Li-Yan Zhao, Wan-Ming Zhang
Feb 25, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rui Li, Yan Xie
Mar 1, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Salime Bazban-ShotorbaniMorteza Mahmoudi
Mar 16, 2017·Biotechnology and Bioengineering·Bojiao YinMichael J Betenbaugh
Nov 5, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Songzhi XieXiaohong Li
Feb 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Imran Shair MohammadLifang Yin
Jul 13, 2018·Biomaterials Science·Chenwei WuChuan Zhang
Jul 17, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mayada M ElgoharyAhmed O Elzoghby
Sep 2, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Meng WangJianqing Gao
Oct 22, 2018·Ecotoxicology and Environmental Safety·Guizhu WuLu Liu
Nov 18, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jia SongHaiyan Hu
Nov 30, 2018·Frontiers in Pharmacology·Canan G Nebigil, Laurent Désaubry
Dec 12, 2018·International Journal of Pharmaceutics·Nisar Ul KhaliqSoon Hong Yuk
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 20, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MalvezziE Negri
May 24, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hangting HuTatiana K Bronich
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MalvezziE Negri
May 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chuangnian ZhangDeling Kong

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Methods Mentioned

BETA
acetylation
nuclear
X-ray
dynamic light scattering
transmission electron microscopy
flow cytometry
fluorescence inverted microscopy
Assay

Software Mentioned

Image J

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