Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Xuechen QianAiguo Wu

Abstract

Ultrasound cavitation therapy has attracted much attention in recent years because the cavitation of microbubbles can be leveraged to boost the infiltration of chemotherapeutic drugs into cancer tissues. For breast cancer therapy, most of the previously reported microbubbles lack specific targeting capacity and permeability. In this study, we have successfully fabricated Y1 receptor ligand (NPY)-modified bubbles, and examined their therapeutic efficacies as size-dependent functions with or without NPY targeting. To achieve this, four types of micro-scale bubbles (MBs or MBs-NPY) and nano-scale bubbles (NBs or NBs-NPY) were comprehensively evaluated. In vivo results indicated that the NBs-NPY group with doxorubicin (DOX) under ultrasound irradiation showed a high tumor suppression effect and a prolonged survival time. Furthermore, the NBs-NPY with DOX group exhibited minimal damage to mouse vital organs, which points to the considerable tolerance of the proposed nanosystem for efficacious breast cancer therapy. In summary, these findings suggest that the developed NPY-targeted NBs could have a broad application prospect in ultrasound cavitation chemotherapy of Y1 receptor-overexpressed breast cancer.

References

Jul 30, 2010·Journal of Medicinal Chemistry·Wei Xia, Philip S Low
Jun 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·You Han Bae, Kinam Park
Sep 21, 2013·Nature·Philippe L BedardLillian L Siu
Nov 30, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhiting DengHairong Zheng
Jan 28, 2016·Regenerative Biomaterials·Juan LiAiguo Wu
Aug 19, 2016·International Journal of Nanomedicine·Xiaozhou FanKejing Fang
Sep 7, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xubo ZhaoPeng Liu
Dec 17, 2016·Cancer Discovery·Marco DemariaJudith Campisi
Feb 27, 2017·Colloids and Surfaces. B, Biointerfaces·Fatemeh Baghbani, Fathollah Moztarzadeh
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 1, 2018·Colloids and Surfaces. B, Biointerfaces·Giovanna PeruzziCarlo Massimo Casciola
Oct 20, 2018·ACS Applied Materials & Interfaces·Adem YildirimAndrew P Goodwin
Jan 10, 2019·Physics in Medicine and Biology·Catherine PaverdConstantin Coussios
Apr 8, 2020·Neuro-oncology Practice·Petra HuehnchenMatthias Endres

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Citations

Jul 27, 2021·Frontiers in Cell and Developmental Biology·Yinqiong HuangShu Lin
Aug 24, 2021·Frontiers in Endocrinology·Shu-Ting LinSi-Qing Cai

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Methods Mentioned

BETA
Dynamic Light Scattering
transmission
scanning electron microscopy
flow cytometry
light microscopy

Software Mentioned

SPSS

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