PMID: 6113540Apr 27, 1981Paper

Active transport of Ca2+ in bacteria: bioenergetics and function

Molecular and Cellular Biochemistry
R Devés, A F Brodie

Abstract

The bioenergetics of Ca2+ transport in bacteria are discussed with special emphasis on the interrelationship between transport and other cellular functions such as substrate oxidation by the respiratory chain and oxidative phosphorylation. The unusual polarity of Ca2+ movement provides an exceptional tool to compare active transport and other ATP requiring or generating processes since this ion is actively taken up by everted vesicles in which the coupling-factor ATPase is exposed to the external medium. As inferred from studies with everted vesicles, the active extrusion of Ca2+ by whole cells can be accomplished by substrate driven respiration, hydrolysis of ATP or as in the case of Streptococcus faecalis by a nonhydrolytic unknown process which involves ATP directly. Substrate oxidation and the hydrolysis of ATP result in the generation of a pH gradient which can energize the Ca2+ uptake directly (Ca2+/H+ antiport) or via a secondary Na+ gradient (Ca2+/Na+ antiport). In contrast to exponentially growing cells sporulating Bacilli accumulate Ca2+ during the synthesis of dipicolinic acid. Studies involving Ca2+ transport provided evidence in support of the hypothesis that the Mg2+ ATPase from Escherichia coli not only provides ...Continue Reading

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Citations

Jan 1, 1987·Cancer Metastasis Reviews·J F WhitfieldP R Walker
Mar 1, 2011·Annual Review of Biophysics·Michael G Palmgren, Poul Nissen
Jan 1, 1982·Annals of the New York Academy of Sciences·J Bürkler, M Solioz
Jan 1, 1982·Bioscience Reports·A C Durham, J M Walton
Jun 26, 2007·Molecular Microbiology·Jeffrey L BoseEric V Stabb

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